Protein Domain : IPR020045

Type:  Domain Name:  5'-3' exonuclease, C-terminal domain
Description:  This entry represents the C-terminal domain of 5' to 3' exonucleases. The 5'-3' exonucleases are conserved in organisms as diverse as bacteriophage and mammals. It adopts a SAM fold consisting of 4-5 helices packed into a bundle of two orthogonally packed alpha-hairpins. This domain is involved in interactions with DNA and proteins. 5' to 3' exonucleases that contain this domain include:Bacteriophage T4 RNase H, which has sequence similarity to the RAD2 family of eukaryotic proteins [].5' to 3' exonuclease domain of DNA polymerase Taq, which is homologous to Escherichia coli DNA polymerase I (pol I) [, ].Bacteriophage T5 5'-exonuclease, which are structure-specific endonucleases [].Flap endonuclease-1 (Fen-1 nuclease), a structure specific nuclease that is an essential enzyme for eukaryotic DNA replication and repair []. Short Name:  5-3_exonuclease_C
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0 Child Features

1 Contains

DB identifier Type Name
IPR008918 Conserved_site Helix-hairpin-helix motif, class 2

3 Cross Referencess

Identifier
PF01367
PF09293
SSF47807

6 Found Ins

DB identifier Type Name
IPR002298 Family DNA polymerase A
IPR006084 Family XPG/Rad2 endonuclease
IPR001044 Family XPG/Rad2 endonuclease, eukaryotes
IPR002421 Domain 5'-3' exonuclease, N-terminal
IPR018320 Family DNA polymerase 1
IPR019973 Family Flap structure-specific endonuclease, archaea

2 GO Annotations

GO Term Gene Name
GO:0003677 IPR020045
GO:0003824 IPR020045

2 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR020045
GO:0003824 IPR020045

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
432344 D8TFQ4 PAC:15402763 Selaginella moellendorffii 218  
432343 D8TFQ3 PAC:15402760 Selaginella moellendorffii 112  
105035 D8RZ80 PAC:15411871 Selaginella moellendorffii 277  
175620 D8RZD7 PAC:15422004 Selaginella moellendorffii 401  
111465 D8S952 PAC:15410492 Selaginella moellendorffii 377  
54861 D8SHJ8 PAC:15420886 Selaginella moellendorffii 363  
85061 D8R3Y1 PAC:15416989 Selaginella moellendorffii 552  
423862 D8SN19 PAC:15402375 Selaginella moellendorffii 137  
46232 D8SN35 PAC:15414957 Selaginella moellendorffii 273  
424808 D8SR31 PAC:15405160 Selaginella moellendorffii 472  
424811 D8SR34 PAC:15405177 Selaginella moellendorffii 443  
46231 D8SR51 PAC:15414956 Selaginella moellendorffii 273  
408336 D8R7Z1 PAC:15421025 Selaginella moellendorffii 340  
410274 D8RE83 PAC:15404112 Selaginella moellendorffii 454  
evm.model.supercontig_107.42 PAC:16405346 Carica papaya 564  
evm.model.supercontig_140.34 PAC:16408879 Carica papaya 868  
evm.model.supercontig_17.163 PAC:16410659 Carica papaya 275  
evm.model.supercontig_3.434 PAC:16416740 Carica papaya 340  
evm.model.supercontig_48.229 PAC:16420872 Carica papaya 435  
evm.model.supercontig_57.89 PAC:16422915 Carica papaya 291  
evm.model.supercontig_9.358 PAC:16428266 Carica papaya 211  
29728.m000839 B9SLH3 PAC:16806909 Ricinus communis 411  
29822.m003372 B9RUC5 PAC:16809742 Ricinus communis 1641  
30026.m001514 B9S8I1 PAC:16815899 Ricinus communis 629  
30128.m008993 B9RFS3 PAC:16818577 Ricinus communis 345  
30147.m013758 B9R9D0 PAC:16819775 Ricinus communis 586  
30174.m008956 B9RDJ8 PAC:16822599 Ricinus communis 609  
29270.m000055 B9TBG6 PAC:16802591 Ricinus communis 409  
29654.m000301 B9SU84 PAC:16804917 Ricinus communis 576  
29641.m000385 B9SX53 PAC:16804489 Ricinus communis 246  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9699635
            8674116
            9874768
            10666572
            7637814