Protein Domain : IPR002298

Type:  Family Name:  DNA polymerase A
Description:  DNA carries the biological information that instructs cells how to exist in an ordered fashion. Accurate replication is thus one of the most important events in the cell life cycle. This function is mediated by DNA-directed DNA polymerases, which add nucleotide triphosphate (dNTP) residues to the 3'-end of the growing DNA chain, using a complementary DNA as template. Small RNA molecules are generally used as primers for chain elongation, although terminal proteins may also be used. DNA-dependent DNA polymerases have been grouped into families, denoted A, Band X, on the basis of sequence similarities [, ]. Members of family A, which includes bacterial and bacteriophage polymerases, share significant similarity to Escherichia colipolymerase I; hence family A is also known as the pol I family. The bacterial polymerases also contain an exonuclease activity, which is coded for in the N-terminal portion. Three motifs, A, B and C [], are seen to be conserved across all DNA polymerases, with motifs A and C also seen in RNA polymerases. They are centred on invariant residues, and their structural significance was implied from the Klenow (E. coli) structure. Motif A contains a strictly-conserved aspartate at the junction of a beta-strand and an alpha-helix; motif B contains an alpha-helix with positive charges; and motif C has a doublet of negative charges, located in a beta-turn-beta secondary structure [].This entry represents the DNA-polymerase A family. Short Name:  DNA_polymerase_A
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1 Child Features

DB identifier Type Name
IPR018320 Family DNA polymerase 1

9 Contains

DB identifier Type Name
IPR001098 Domain DNA-directed DNA polymerase, family A, palm domain
IPR012337 Domain Ribonuclease H-like domain
IPR020045 Domain 5'-3' exonuclease, C-terminal domain
IPR008918 Conserved_site Helix-hairpin-helix motif, class 2
IPR002562 Domain 3'-5' exonuclease domain
IPR020046 Domain 5'-3' exonuclease, alpha-helical arch, N-terminal
IPR002421 Domain 5'-3' exonuclease, N-terminal
IPR019760 Conserved_site DNA-directed DNA polymerase, family A, conserved site
IPR015361 Domain Taq polymerase, thermostable, exonuclease region

1 Cross References

Identifier
PR00868

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0003887 IPR002298
GO:0006261 IPR002298

2 Ontology Annotations

GO Term Gene Name
GO:0003887 IPR002298
GO:0006261 IPR002298

0 Parent Features

957 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
82310 D8QZ15 PAC:15410421 Selaginella moellendorffii 788  
evm.model.supercontig_205.2 PAC:16413239 Carica papaya 380  
evm.model.supercontig_97.33 PAC:16429068 Carica papaya 937  
29794.m003462 B9RS63 PAC:16808821 Ricinus communis 2154  
28953.m000079 B9T8Y9 PAC:16802019 Ricinus communis 267  
29666.m001473 B9SAH0 PAC:16805167 Ricinus communis 963  
Cucsa.059830.2 PAC:16954813 Cucumis sativus 1029  
Cucsa.059830.1 PAC:16954812 Cucumis sativus 1126  
Cucsa.161460.2 PAC:16965508 Cucumis sativus 2127  
Cucsa.161460.1 A0A0A0LS46 PAC:16965507 Cucumis sativus 2139  
orange1.1g002293m A0A067E5F4 PAC:18098412 Citrus sinensis 940  
orange1.1g001207m A0A067EH89 PAC:18098410 Citrus sinensis 1123  
orange1.1g001267m A0A067EGF6 PAC:18098411 Citrus sinensis 1112  
orange1.1g000107m A0A067GWC2 PAC:18096851 Citrus sinensis 2191  
AT4G32700.2 Q588V7 PAC:19648824 Arabidopsis thaliana 2154  
AT3G20540.2 F4JEQ3 PAC:19663034 Arabidopsis thaliana 1049  
AT3G20540.1 Q84ND9 PAC:19663035 Arabidopsis thaliana 1034  
AT1G50840.1 F4I6M1 PAC:19651283 Arabidopsis thaliana 1050  
Thhalv10024191m V4MM54 PAC:20193557 Eutrema salsugineum 1908  
Thhalv10019969m V4LBK2 PAC:20182910 Eutrema salsugineum 1050  
Thhalv10011195m V4JY12 PAC:20184500 Eutrema salsugineum 1088  
Ciclev10007228m PAC:20792714 Citrus clementina 1988  
Ciclev10007318m V4UH82 PAC:20793631 Citrus clementina 1043  
Ciclev10007319m V4UH82 PAC:20793632 Citrus clementina 1043  
Ciclev10007282m V4TY17 PAC:20793630 Citrus clementina 1164  
Lus10040048 PAC:23173453 Linum usitatissimum 669  
Lus10019619 PAC:23142570 Linum usitatissimum 1163  
Lus10007673 PAC:23165686 Linum usitatissimum 500  
Lus10022115 PAC:23146488 Linum usitatissimum 2163  
Potri.011G136900.1 PAC:27001716 Populus trichocarpa 998  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2196557
            3479792