3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0003676 | IPR002562 |
| GO:0008408 | IPR002562 |
| GO:0006139 | IPR002562 |
| Type: | Domain | Name: | 3'-5' exonuclease domain |
| Description: | This domain is responsible for the 3'-5' exonuclease proofreading activity of Escherichia coliDNA polymerase I (polI) and other enzymes, it catalyses the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli polI it is also found in the Werner syndrome helicase (WRN), focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D) [].Werner syndrome is a human genetic disorder causing premature aging; the WRN protein has helicase activity in the 3'-5' direction [, ]. The FFA-1 protein is required for formation of a replication foci and also has helicase activity; it is a homologue of the WRN protein []. RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome. | Short Name: | 3'-5'_exonuclease_dom |
| GO Term | Gene Name |
|---|---|
| GO:0003676 | IPR002562 |
| GO:0008408 | IPR002562 |
| GO:0006139 | IPR002562 |
