| Type: | Family | Name: | Ribonuclease H1, eukaryote |
| Description: | This entry represents ribonuclease H1 (RNase H1; ) from eukaryotes. RNase H1 specifically degrades the RNA of RNA-DNA hybrids through endonucleolytic cleavage to 5'-phosphomonoester in the presence of magnesium. Human RNase H1 has a DNA-binding channel that, together with the conserved phosphate-binding pocket, confers specificity for the B form and 2'-deoxy form of DNA; the RNA strand is recognised by four consecutive 2'-OH groups and cleaved by a two-metal ion mechanism []. | Short Name: | RNase_H1_euk |
