1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR009027 | Domain | Ribosomal protein L9/RNase H1, N-terminal |
| Type: | Domain | Name: | Ribonuclease H1, N-terminal |
| Description: | This entry represents the N-terminal domain of RNase HI, which has a 3-layer alpha/beta/alpha structure []. This domain is lacking in retroviral and prokaryotic enzymes, but shows a striking structural similarity to the ribosomal protein L9 N-terminal domain, and may function as a regulatory RNA-binding module. However, the topology of this domain differs from structures of known RNA binding domains such as the double-stranded RNA binding domain (dsRBD), the hnRNP K homology (KH) domain and the RNP motif. Eukaryotic RNases HI possess either one or two copies of this small N-terminal domain, in addition to the well-conserved catalytic RNase H domain. RNase HI belongs to the family of ribonuclease H enzymes that recognise RNA:DNA hybrids and degrade the RNA component. | Short Name: | RNase_H1_N |
| DB identifier | Type | Name |
|---|---|---|
| IPR009027 | Domain | Ribosomal protein L9/RNase H1, N-terminal |
