Protein Domain : IPR009057

Type:  Domain Name:  Homeodomain-like
Description:  Homeodomain proteins are transcription factors that share a related DNA binding homeodomain []. The homeodomain was first identified in a number of Drosophila homeotic and segmentation proteins, but is now known to be well conserved in many other animals, including vertebrates. The domain binds DNA through a helix-turn-helix (HTH) structure. The HTH motif is characterised by two alpha-helices, which make intimate contacts with the DNA and are joined by a short turn. The second helix binds to DNA via a number of hydrogen bonds and hydrophobic interactions, which occur between specific side chains and the exposed bases and thymine methyl groups within the major groove of the DNA. The first helix helps to stabilise the structure. Many proteins contain homeodomains, including Drosophila Engrailed, yeast mating type proteins, hepatocyte nuclear factor 1a and HOX proteins.The homeodomain motif is very similar in sequence and structure to domains in a wide range of DNA-binding proteins, including recombinases, Myb proteins, GARP response regulators, human telomeric proteins (hTRF1), paired domain proteins (PAX), yeast RAP1, centromere-binding proteins CENP-B and ABP-1, transcriptional regulators (TyrR), AraC-type transcriptional activators, and tetracycline repressor-like proteins (TetR, QacR, YcdC) [, , ]. Short Name:  Homeodomain-like
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18 Child Features

DB identifier Type Name
IPR015195 Domain SLIDE domain
IPR001356 Domain Homeobox domain
IPR001005 Domain SANT/Myb domain
IPR007526 Domain SWIRM domain
IPR006600 Domain HTH CenpB-type DNA-binding domain
IPR006455 Domain Homeodomain, ZF-HD class
IPR018060 Domain DNA binding HTH domain, AraC-type
IPR002197 Domain DNA binding HTH domain, Fis-type
IPR001647 Domain DNA-binding HTH domain, TetR-type
IPR023082 Domain Homeo-prospero domain
IPR014875 Domain Mor transcription activator
IPR007889 Domain DNA binding HTH domain, Psq-type
IPR030828 Domain TyrR family, helix-turn-helix domain
IPR002622 Domain Transposase, Synechocystis PCC 6803
IPR015010 Domain Rap1 Myb domain
IPR024978 Domain Homeodomain, phBC6A51-type
IPR025246 Domain Transposase IS30-like HTH domain
IPR006120 Domain Resolvase, HTH domain

7 Contains

DB identifier Type Name
IPR017930 Domain Myb domain
IPR000047 Conserved_site Helix-turn-helix motif
IPR017970 Conserved_site Homeobox, conserved site
IPR020479 Domain Homeodomain, metazoa
IPR019737 Conserved_site Homeobox engrailed-type, conserved site
IPR015126 Domain Mu DNA binding, I gamma subdomain
IPR015280 Domain Rap1, DNA-binding domain

2 Cross Referencess

Identifier
G3DSA:1.10.10.60
SSF46689

16 Found Ins

DB identifier Type Name
IPR002514 Family Transposase IS3/IS911family
IPR017894 Domain HTH domain, IS21 transposase-type
IPR016233 Family Homeobox protein Pitx/unc30
IPR010113 Family Nif-specific regulatory protein
IPR014317 Family Transcription activator PspF
IPR010114 Family Signal transduction response regulator, nitrogen regulation NR(I)
IPR011785 Family Transcription regulator PpsR
IPR005412 Family DNA-binding protein Fis
IPR014264 Family Signal transduction response regulator, PEP-CTERM system, putative
IPR012704 Family Signal transduction response regulator, propionate catabolism, transcriptional regulator PrpR
IPR000972 Family Octamer-binding transcription factor
IPR003022 Family Transcription factor Otx2
IPR003025 Family Transcription factor Otx
IPR003026 Family Transcription factor Otx1
IPR019915 Family Transcription regulator, pyrimidine utilisation, RutR
IPR003220 Domain InsA N-terminal domain

1 GO Annotation

GO Term Gene Name
GO:0003677 IPR009057

1 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR009057

0 Parent Features

200326 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
410828 D8RG00 PAC:15408646 Selaginella moellendorffii 549  
448754 D8T9Y2 PAC:15408259 Selaginella moellendorffii 398  
18196 D8RGY1 PAC:15420843 Selaginella moellendorffii 104  
441102 D8RGH7 PAC:15405429 Selaginella moellendorffii 299  
93784 D8RGZ8 PAC:15401357 Selaginella moellendorffii 157  
135843 D8TAX2 PAC:15417235 Selaginella moellendorffii 275  
73113 D8RII7 PAC:15404458 Selaginella moellendorffii 59  
68039 D8RJB4 PAC:15411313 Selaginella moellendorffii 222  
431616 D8TD80 PAC:15402132 Selaginella moellendorffii 140  
19476 D8RLG4 PAC:15403593 Selaginella moellendorffii 87  
39810 D8RLN8 PAC:15420957 Selaginella moellendorffii 55  
66294 D8RM02 PAC:15406996 Selaginella moellendorffii 216  
270954 Q0Q432 PAC:15401824 Selaginella moellendorffii 840  
412944 D8RMU5 PAC:15415443 Selaginella moellendorffii 297  
96986 D8RME1 PAC:15411746 Selaginella moellendorffii 541  
39139 D8QVN0 PAC:15415740 Selaginella moellendorffii 59  
404134 D8QUD7 PAC:15407758 Selaginella moellendorffii 312  
404720 D8QW69 PAC:15412473 Selaginella moellendorffii 166  
438163 D8QUM4 PAC:15418945 Selaginella moellendorffii 804  
4561 PAC:15416615 Selaginella moellendorffii 168  
78045 D8QVD0 PAC:15418493 Selaginella moellendorffii 336  
78396 PAC:15420897 Selaginella moellendorffii 84  
78481 D8QU17 PAC:15421531 Selaginella moellendorffii 68  
78303 D8QVM2 PAC:15420680 Selaginella moellendorffii 89  
78848 D8QVL9 PAC:15402279 Selaginella moellendorffii 89  
79245 PAC:15422841 Selaginella moellendorffii 84  
413208 D8RNP6 PAC:15412850 Selaginella moellendorffii 817  
413205 D8RNP3 PAC:15412845 Selaginella moellendorffii 762  
39481 D8RNP8 PAC:15418103 Selaginella moellendorffii 87  
413266 D8RNW4 PAC:15413019 Selaginella moellendorffii 303  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7707374
            10377888
            12215502
            9739097