Protein Domain : IPR012704

Type:  Family Name:  Signal transduction response regulator, propionate catabolism, transcriptional regulator PrpR
Description:  Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions []. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk []. These pathways have been adapted to response to a wide variety of stimuli, including nutrients, cellular redox state, changes in osmolarity, quorum signals, antibiotics, and more []. Two-component systems are comprised of a sensor histidine kinase (HK) and its cognate response regulator (RR) []. The HK catalyses its own auto-phosphorylation followed by the transfer of the phosphoryl group to the receiver domain on RR; phosphorylation of the RR usually activates an attached output domain, which can then effect changes in cellular physiology, often by regulating gene expression. Some HK are bifunctional, catalysing both the phosphorylation and dephosphorylation of their cognate RR. The input stimuli can regulate either the kinase or phosphatase activity of the bifunctional HK.A variant of the two-component system is the phospho-relay system. Here a hybrid HK auto-phosphorylates and then transfers the phosphoryl group to an internal receiver domain, rather than to a separate RR protein. The phosphoryl group is then shuttled to histidine phosphotransferase (HPT) and subsequently to a terminal RR, which can evoke the desired response [, ].This entry represents the signal transduction response regulator PrpR. At least five distinct pathways exist for the catabolism of propionate by way of propionyl-CoA. Members of this family represent the transcriptional regulatory protein PrpR which is, in most cases, divergently transcribed from the operon that encodes the genes involved in the methylcitric acid cycle of propionate catabolism. This protein is required for the expression of the proteins involved in this pathway []. 2-methylcitric acid, an intermediate in this pathway, has been proposed to be a co-activator of PrpR []. Short Name:  Sig_transdc_resp-reg_PrpR
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0 Child Features

5 Contains

DB identifier Type Name
IPR009057 Domain Homeodomain-like
IPR000014 Domain PAS domain
IPR002197 Domain DNA binding HTH domain, Fis-type
IPR002078 Domain RNA polymerase sigma factor 54 interaction domain
IPR010524 Domain Signal transduction response regulator, propionate catabolism activator, N-terminal

1 Cross References

Identifier
TIGR02329

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0000156 IPR012704
GO:0003677 IPR012704
GO:0005524 IPR012704
GO:0000160 IPR012704
GO:0019629 IPR012704
GO:0005737 IPR012704

6 Ontology Annotations

GO Term Gene Name
GO:0000156 IPR012704
GO:0003677 IPR012704
GO:0005524 IPR012704
GO:0000160 IPR012704
GO:0019629 IPR012704
GO:0005737 IPR012704

0 Parent Features

0 Proteins

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12372152
            10966457
            16176121
            18076326
            11934609
            11489844
            10648513
            9851993