Protein Domain : IPR010113

Type:  Family Name:  Nif-specific regulatory protein
Description:  This entry represents NifA, a DNA-binding regulatory protein for nitrogen fixation. Not included in this group are: the homologue in Aquifex aeolicus(which lacks nitrogenase), transcriptional activators of alternative nitrogenases (VFe or FeFe instead of MoFe), and truncated forms.In diazotrophic proteobacteria, the sigma54-dependent activator NifA activates transcription of the nif (nitrogen fixation) genes by a conserved mechanism common to members of the enhancer binding protein family. Although NifA proteins have similar domain structures, both transcriptional regulation of nifA expression and posttranslational regulation of NifA activity by oxygen and fixed nitrogen vary significantly from one organism to another. In Klebsiella pneumoniaeand Azotobacter vinelandii, nifA is co-ordinately transcribed with a second gene, nifL, whose product inhibits NifA activity in response to oxygen and fixed nitrogen []. Short Name:  Nif-specific_regulatory_prot

0 Child Features

4 Contains

DB identifier Type Name
IPR009057 Domain Homeodomain-like
IPR003018 Domain GAF domain
IPR002197 Domain DNA binding HTH domain, Fis-type
IPR002078 Domain RNA polymerase sigma factor 54 interaction domain

1 Cross References

Identifier
TIGR01817

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003700 IPR010113
GO:0006355 IPR010113
GO:0009399 IPR010113

3 Ontology Annotations

GO Term Gene Name
GO:0003700 IPR010113
GO:0006355 IPR010113
GO:0009399 IPR010113

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11325935