Protein Domain : IPR003022

Type:  Family Name:  Transcription factor Otx2
Description:  Otx proteins constitute a class of vertebrate homeodomain-containing transcription factors that have been shown to be essential for anteriorhead formation, including brain morphogenesis. They are orthologous to the product of the Drosophila head gap gene, orthodenticle (Otd), and appear toplay similar roles in both, since the developmental abnormalities caused by disruption of these transcription factors in one, can be recovered bysubstitution of the factor(s) from the other. Such studies have provided strong evidence that there exists a conserved genetic programme for insectand mammalian brain development, which presumably arose in a more primitive common ancestor [, ].Two vertebrate orthodenticle-related transcription factors have been indentified, Otx1 and Otx2, which have sizes of 355 and 289 residues respectively. They contain a bicoid-like homeodomain, which features aconserved lysine residue at position 9 of the DNA recognition helix, which is thought to confer high-affinity binding to TAATCC/T elements on DNA [].Otd-like transcription factors have also been found in zebrafish and certain lamprey species. Mice completely lacking Otx2 (due to targeted gene disruption) die during early embryogenesis. Analysis reveals that they lack the neuroectodermthat is destined to become the forebrain, midbrain and rostral hindbrain. They also show major abnormalities in their body plan. Mice that haveartificially-reduced levels of Otx2 develop head abnormalities reminiscent of otocephaly []. Short Name:  Otx2_TF
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0 Child Features

4 Contains

DB identifier Type Name
IPR009057 Domain Homeodomain-like
IPR001356 Domain Homeobox domain
IPR017970 Conserved_site Homeobox, conserved site
IPR013851 Domain Transcription factor Otx, C-terminal

2 Cross Referencess

Identifier
PTHR24329:SF131
PR01257

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003677 IPR003022
GO:0003700 IPR003022
GO:0007275 IPR003022
GO:0005634 IPR003022

4 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR003022
GO:0003700 IPR003022
GO:0007275 IPR003022
GO:0005634 IPR003022

1 Parent Features

DB identifier Type Name
IPR003025 Family Transcription factor Otx

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7590242
            10199636
            10375352
            10440864