Protein Domain : IPR017970

Type:  Conserved_site Name:  Homeobox, conserved site
Description:  The homeobox domain or homeodomain was first identified in a number of drosophila homeotic and segmentation proteins, but is now known to be well-conserved in many other animals, including vertebrates [, ]. Hox genes encode homeodomain-containing transcriptional regulators that operate differential genetic programs along the anterior-posterior axis of animal bodies []. The domain binds DNA through a helix-turn-helix (HTH) structure. The HTH motif is characterised by two alpha-helices, which make intimate contacts with the DNA and are joined by a short turn. The second helix binds to DNA via a number of hydrogen bonds and hydrophobic interactions, which occur between specific side chains and the exposed bases and thymine methyl groups within the major groove of the DNA. The first helix helps to stabilise the structure. The motif is very similar in sequence and structure in a wide range of DNA-binding proteins (e.g., cro and repressor proteins, homeotic proteins, etc.). One of the principal differences between HTH motifs in these different proteins arises from the stereo-chemical requirement for glycine in the turn which is needed to avoid steric interference of the beta-carbon with the main chain: for cro and repressor proteins the glycine appears to be mandatory, while for many of the homeotic and other DNA-binding proteins the requirement is relaxed. Short Name:  Homeobox_CS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00027

16 Found Ins

DB identifier Type Name
IPR009057 Domain Homeodomain-like
IPR001356 Domain Homeobox domain
IPR000047 Conserved_site Helix-turn-helix motif
IPR017112 Family Homeobox protein Hox9
IPR016362 Family POU-domain transcription factor, class 3
IPR013847 Domain POU domain
IPR016233 Family Homeobox protein Pitx/unc30
IPR000747 Domain Homeodomain engrailed
IPR020479 Domain Homeodomain, metazoa
IPR000972 Family Octamer-binding transcription factor
IPR015584 Family POU domain-containing protein, class 4-related
IPR015585 Family POU domain-containing protein, class 5
IPR015586 Family Pituitary-specific positive transcription factor 1
IPR003022 Family Transcription factor Otx2
IPR003025 Family Transcription factor Otx
IPR003026 Family Transcription factor Otx1

2 GO Annotations

GO Term Gene Name
GO:0043565 IPR017970
GO:0006355 IPR017970

2 Ontology Annotations

GO Term Gene Name
GO:0043565 IPR017970
GO:0006355 IPR017970

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2568852
            1357790
            12445403