Protein Domain : IPR007889

Type:  Domain Name:  DNA binding HTH domain, Psq-type
Description:  The psq-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50 amino acids present in eukaryotic proteins of the Pipsqueak family.This family is named after the Drosophila pipsqueak protein, containing a DNA-binding domain that consists of four tandem repeats of the psq motif [].Proteins of the Pipsqueak family occur in vertebrates, insects, nematodes, and fungi. Three subgroups of the family have been described: BTB, E93 and CENP-B. Pipsqueak and the other proteins of the BTB group (Broad-Complex, Tramtrack,Bric a brac) contain a BTB protein-protein interaction domain in the N-terminal part, and the psq-type HTH domain(s) occur in the C-terminal part. Many BTB proteins are transcriptional regulators and the psq-type HTH domain binds DNA. The Drosophila cell death regulating protein E93 and human orthologs form the second subgroup and can contain the psq-type HTH at varying positions. The human centromere protein B (CENP-B) and the other members of the CENP-B group contain a psq-type DNA-binding domain in the N-terminal part and often a dimerisation domain in the C-terminal part. The CENP-B group includes fungal transposases that, however, lack the N-terminal extremity of the psq-type HTH domain [].The structure of human CENP-B shows that the N-terminal part of the DNA binding domain is composed of three alpha-helices. The second and third helices connected via a turn comprise the helix-turn-helix motif. Helix 3 is termed the recognition helix as it binds the DNA major groove, like in other HTHs []. Short Name:  HTH_Psq

0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF04218
PF05225
PS50960

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0003677 IPR007889

1 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR007889

1 Parent Features

DB identifier Type Name
IPR009057 Domain Homeodomain-like

27 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Sphfalx0037s0057.1.p PAC:32606964 Sphagnum fallax 1565  
Sphfalx0131s0041.2.p PAC:32606502 Sphagnum fallax 778  
Sphfalx0131s0041.1.p PAC:32606501 Sphagnum fallax 778  
Sphfalx0050s0095.1.p PAC:32608519 Sphagnum fallax 246  
Sphfalx0222s0014.1.p PAC:32630452 Sphagnum fallax 197  
Pp3c24_4020V3.1.p A9RN30 PAC:32910499 Physcomitrium patens 430  
Pp3c8_6570V3.1.p A0A2K1K6D8 PAC:32965287 Physcomitrium patens 430  
Pum1130s0003.1.p A0A1X6NMJ6 PAC:38006212 Porphyra umbilicalis 552  
Cz09g08220.t1 PAC:38238860 Chromochloris zofingiensis 961  
Sphmag04G130700.1.p PAC:41930180 Sphagnum magellanicum 246  
Sphmag03G062100.1.p PAC:41922829 Sphagnum magellanicum 198  
Sphfalx14G055300.1.p PAC:41952520 Sphagnum fallax 147  
Sphfalx04G125600.1.p PAC:41957500 Sphagnum fallax 246  
Sphfalx03G064300.1.p PAC:41983853 Sphagnum fallax 197  
CepurR40.12G015400.2.p PAC:43014460 Ceratodon purpureus R40 342  
CepurR40.12G015700.1.p PAC:43016346 Ceratodon purpureus R40 278  
CepurR40.12G015400.1.p PAC:43014459 Ceratodon purpureus R40 409  
CepurR40.12G016000.1.p PAC:43014977 Ceratodon purpureus R40 409  
CepurGG1.12G016200.1.p PAC:43054681 Ceratodon purpureus GG1 278  
CepurGG1.12G016600.1.p PAC:43055258 Ceratodon purpureus GG1 409  
CepurGG1.12G016600.4.p PAC:43055260 Ceratodon purpureus GG1 379  
CepurGG1.12G016600.2.p PAC:43055259 Ceratodon purpureus GG1 408  
CepurGG1.12G016600.3.p PAC:43055261 Ceratodon purpureus GG1 378  
CepurGG1.12G015900.1.p PAC:43055610 Ceratodon purpureus GG1 409  
CepurGG1.1G179800.1.p PAC:43034366 Ceratodon purpureus GG1 203  
Thupl.29377845s0003.1.p PAC:44966908 Thuja plicata 73  
Thupl.29379924s0007.1.p PAC:44954515 Thuja plicata 138  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11726497
            9774480
            11976954