Protein Domain : IPR000742

Type:  Domain Name:  EGF-like domain
Description:  A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF) has been shown [, , , , , ] to be present, in a more or less conserved form, in a large number of other, mostly animal proteins.The functional significance of EGF domains in what appear to be unrelated proteins is not yet clear. However, a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved indisulphide bonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet. Subdomains between the conserved cysteines vary in length. Short Name:  EGF-like_dom
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0 Child Features

5 Contains

DB identifier Type Name
IPR001881 Domain EGF-like calcium-binding domain
IPR013111 Domain EGF-like domain, extracellular
IPR013032 Conserved_site EGF-like, conserved site
IPR018097 Conserved_site EGF-like calcium-binding, conserved site
IPR000152 PTM EGF-type aspartate/asparagine hydroxylation site

3 Cross Referencess

Identifier
PF00008
PS50026
SM00181

22 Found Ins

DB identifier Type Name
IPR002049 Domain Laminin EGF domain
IPR002396 Family Selectin superfamily
IPR016317 Family Pro-epidermal growth factor
IPR016316 Family Thrombomodulin
IPR016348 Family L-selectin
IPR008297 Family Notch
IPR022355 Family Neurogenic locus Notch 4
IPR018250 Family Neuregulin-1
IPR012111 Family Hemolectin/hemocytin
IPR008294 Family Meprin alpha/beta subunit
IPR014394 Family Coagulation factor XIIa/hepatocyte growth factor activator
IPR003056 Family GPCR, family 2, CD97 antigen
IPR017048 Family Fibulin-1
IPR011398 Family Fibrillin
IPR015446 Family Bone morphogenetic protein 1/tolloid-like protein
IPR012224 Family Peptidase S1A, coagulation factor VII/IX/X/C/Z
IPR011170 Family Growth factor, vaccinia C11R type
IPR015455 Family Thrombospondin-2
IPR015497 Family Epidermal growth factor receptor ligand
IPR017047 Family Teratocarcinoma-derived growth factor Cripto
IPR017369 Family SPAN protein/blastula protease 10
IPR017436 Family Cripto-related protein 3

1 GO Annotation

GO Term Gene Name
GO:0005515 IPR000742

1 Ontology Annotations

GO Term Gene Name
GO:0005515 IPR000742

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
99172 D8RPU4 PAC:15414408 Selaginella moellendorffii 228  
417729 D8S3E8 PAC:15406027 Selaginella moellendorffii 868  
405687 D8QZE1 PAC:15414821 Selaginella moellendorffii 181  
71846 D8SC01 PAC:15404058 Selaginella moellendorffii 178  
407256 D8R4F6 PAC:15417449 Selaginella moellendorffii 666  
77831 D8QTB8 PAC:15421552 Selaginella moellendorffii 752  
30867 D8QTB9 PAC:15417141 Selaginella moellendorffii 687  
440224 D8R9B2 PAC:15403306 Selaginella moellendorffii 281  
evm.model.supercontig_12.4 PAC:16406878 Carica papaya 832  
evm.model.supercontig_1461.2 PAC:16409171 Carica papaya 748  
evm.model.supercontig_2.156 PAC:16412515 Carica papaya 799  
evm.model.supercontig_27.166 PAC:16415541 Carica papaya 835  
evm.model.supercontig_27.170 PAC:16415546 Carica papaya 433  
evm.model.supercontig_27.171 PAC:16415547 Carica papaya 850  
evm.model.supercontig_56.43 PAC:16422751 Carica papaya 615  
evm.model.supercontig_64.160 PAC:16424236 Carica papaya 747  
evm.model.supercontig_64.161 PAC:16424237 Carica papaya 742  
evm.model.supercontig_64.47 PAC:16424280 Carica papaya 843  
evm.model.supercontig_92.12 PAC:16428578 Carica papaya 728  
29747.m001087 B9SFX3 PAC:16807753 Ricinus communis 743  
29747.m001089 B9SFX5 PAC:16807755 Ricinus communis 832  
29755.m000427 B9SNI7 PAC:16807930 Ricinus communis 739  
29755.m000429 B9SNI9 PAC:16807932 Ricinus communis 771  
29784.m000368 B9SXC2 PAC:16808471 Ricinus communis 1517  
29842.m003707 B9RXX5 PAC:16810838 Ricinus communis 1480  
29842.m003713 B9RXY1 PAC:16810844 Ricinus communis 830  
29908.m006156 B9RJ59 PAC:16812974 Ricinus communis 793  
29933.m001463 B9SFF2 PAC:16814190 Ricinus communis 849  
29976.m000491 B9SD70 PAC:16814779 Ricinus communis 457  
30014.m000454 B9SSB8 PAC:16815675 Ricinus communis 759  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3282918
            6607417
            2288911
            6334307
            1522591
            11498013