Protein Domain : IPR013032

Type:  Conserved_site Name:  EGF-like, conserved site
Description:  A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF) has been shown [, , , ] to be present, in a moreor less conserved form, in a large number of other, mostly animal proteins. The list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied. The functional significance of EGF domains inwhat appear to be unrelated proteins is not yet clear. However, a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandinG/H synthase). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in disulphide bonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet.Subdomains between the conserved cysteines vary in length. This entry represents a conserved site in the EGF-like domain. Short Name:  EGF-like_CS
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF12661
PS00022
PS01186

28 Found Ins

DB identifier Type Name
IPR000742 Domain EGF-like domain
IPR001881 Domain EGF-like calcium-binding domain
IPR013111 Domain EGF-like domain, extracellular
IPR002049 Domain Laminin EGF domain
IPR010423 Family Plasmodium ookinete surface Pvs28
IPR002396 Family Selectin superfamily
IPR016317 Family Pro-epidermal growth factor
IPR016316 Family Thrombomodulin
IPR015149 Domain Thrombomodulin-like, EGF-like
IPR016348 Family L-selectin
IPR008297 Family Notch
IPR022355 Family Neurogenic locus Notch 4
IPR018250 Family Neuregulin-1
IPR012111 Family Hemolectin/hemocytin
IPR012013 Family Integrin beta-4 subunit
IPR015442 Family Integrin beta-8 subunit
IPR015812 Family Integrin beta subunit
IPR014394 Family Coagulation factor XIIa/hepatocyte growth factor activator
IPR017048 Family Fibulin-1
IPR011398 Family Fibrillin
IPR015446 Family Bone morphogenetic protein 1/tolloid-like protein
IPR012224 Family Peptidase S1A, coagulation factor VII/IX/X/C/Z
IPR011170 Family Growth factor, vaccinia C11R type
IPR015455 Family Thrombospondin-2
IPR015497 Family Epidermal growth factor receptor ligand
IPR017047 Family Teratocarcinoma-derived growth factor Cripto
IPR017369 Family SPAN protein/blastula protease 10
IPR017050 Family Metallopeptidase, nematode

0 GO Annotation

0 Ontology Annotations

0 Parent Features

37 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
29474 A4SB37 PAC:27420078 Ostreococcus lucimarinus 2031  
40737 A4S8I9 PAC:27417251 Ostreococcus lucimarinus 172  
Glyma.17G248400.5.p K7MNU2 PAC:30480399 Glycine max 687  
Cre03.g157000.t1.1 A0A2K3DW37 PAC:30787575 Chlamydomonas reinhardtii 760  
Bradi4g38020.2.p PAC:31140740 Brachypodium distachyon 729  
Pp3c21_8250V3.4.p A9U3G0 PAC:32916466 Physcomitrium patens 238  
Pp3c21_8250V3.3.p A9U3G0 PAC:32916465 Physcomitrium patens 238  
Pp3c21_8250V3.2.p A9U3G0 PAC:32916464 Physcomitrium patens 238  
Pp3c21_8250V3.1.p A9U3G0 PAC:32916463 Physcomitrium patens 238  
Dusal.0337s00015.1.p PAC:33185205 Dunaliella salina 165  
Dusal.1022s00002.1.p PAC:33188840 Dunaliella salina 615  
Dusal.2746s00001.1.p PAC:33186978 Dunaliella salina 569  
Brdisv1Koz-11029675m.p PAC:33379946 Brachypodium distachyon Koz-1 729  
Brdisv20Bd21Ref1042190m.p PAC:33455700 Brachypodium distachyon Bd21 AnntCtrl 729  
Brdisv1pangenome1055399m.p PAC:33605878 Brachypodium distachyon Pangenome 729  
Brdisv1Adi-121026735m.p PAC:34695560 Brachypodium distachyon Adi-12 729  
Brdisv1Bd21Control1028759m.p PAC:34786718 Brachypodium distachyon Bd21 AsmbCtrl 729  
Brdisv1Koz-31033344m.p PAC:35137578 Brachypodium distachyon Koz-3 700  
Brdisv1Adi-21018845m.p PAC:35296258 Brachypodium distachyon Adi-2 729  
Tp57577_TGAC_v2_mRNA16293 PAC:35979716 Trifolium pratense 829  
AUR62023699-RA PAC:36281873 Chenopodium quinoa 268  
Bobra.55_3s0006.1.p PAC:40709837 Botryococcus braunii 198  
Bobra.55_3s0006.2.p PAC:40709838 Botryococcus braunii 164  
Thint.19G0554900.1.p PAC:40807928 Thinopyrum intermedium 901  
Glyma.17G248400.5.p PAC:41087205 Glycine max 671  
PvUI111.08G063100.1.p PAC:42826533 Phaseolus vulgaris UI111 183  
PvUI111.08G063100.4.p PAC:42826535 Phaseolus vulgaris UI111 129  
CepurR40.8G120000.1.p PAC:42993058 Ceratodon purpureus R40 253  
CepurGG1.8G116500.1.p PAC:43045796 Ceratodon purpureus GG1 253  
CiLak.13G143800.1.p PAC:44274622 Carya illinoinensis Lakota 576  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3282918
            6607417
            2288911
            6334307