| Type: | Domain | Name: | EGF-like domain, extracellular |
| Description: | A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF) has been shown [, , , ] to be present, in a moreor less conserved form, in a large number of other, mostly animal proteins. The list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied. The functional significance of EGF domains inwhat appear to be unrelated proteins is not yet clear. However, a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandinG/H synthase). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in disulphide bonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet.Subdomains between the conserved cysteines vary in length.This entry contains EGF domains found in a variety of extracellular and membrane proteins | Short Name: | EGF_extracell |
| DB identifier | Type | Name |
|---|---|---|
| IPR000742 | Domain | EGF-like domain |
| IPR008297 | Family | Notch |
| IPR012013 | Family | Integrin beta-4 subunit |
| IPR015436 | Family | Integrin beta-6 subunit |
| IPR015439 | Family | Integrin beta-2 subunit |
| IPR015442 | Family | Integrin beta-8 subunit |
| IPR015812 | Family | Integrin beta subunit |
| IPR015437 | Family | Integrin beta-7 subunit |
