Protein Domain : IPR015812

Type:  Family Name:  Integrin beta subunit
Description:  Integrins are the major metazoan receptors for cell adhesion to extracellular matrix proteins and, in vertebrates, also play important roles in certain cell-cell adhesions, make transmembrane connections to the cytoskeleton and activate many intracellular signalling pathways [, ]. The integrin receptors are composed of alpha and beta subunit heterodimers. Each subunit crosses the membrane once, with most of the polypeptide residing in the extracellular space, and has two short cytoplasmic domains. Some members of this family have EGF repeats at the C terminus and also have a vWA domain inserted within the integrin domain at the N terminus.Most integrins recognise relatively short peptide motifs, and in general require an acidic amino acid to be present. Ligand specificity depends upon both the alpha and beta subunits []. There are at least 18 types of alpha and 8 types of beta subunits recognised in humans []. Each alpha subunit tends to associate only with one type of beta subunit, but there are exceptions to this rule []. Each association of alpha and beta subunits has its own binding specificity and signalling properties. Many integrins require activation on the cell surface before they can bind ligands. Integrins frequently intercommunicate, and binding at one integrin receptor activate or inhibit another.Some receptors share a common beta chain while having different alpha chains [, ]. A number of different beta chains, beta-1 to beta-8 are known in higher eukaryotes.This entry represents the family of integrin beta subunit proteins. It also includes integrin beta-like protein 1, whose function is unknown. Short Name:  Integrin_bsu
Paste the following link

9 Child Features

DB identifier Type Name
IPR012013 Family Integrin beta-4 subunit
IPR015436 Family Integrin beta-6 subunit
IPR015439 Family Integrin beta-2 subunit
IPR015442 Family Integrin beta-8 subunit
IPR015437 Family Integrin beta-7 subunit
IPR027071 Family Integrin beta-1 subunit
IPR027067 Family Integrin beta-5 subunit
IPR027068 Family Integrin beta-3 subunit
IPR027070 Family Integrin beta-like protein 1

6 Contains

DB identifier Type Name
IPR002035 Domain von Willebrand factor, type A
IPR013111 Domain EGF-like domain, extracellular
IPR014836 Domain Integrin beta subunit, cytoplasmic domain
IPR013032 Conserved_site EGF-like, conserved site
IPR012896 Domain Integrin beta subunit, tail
IPR002369 Domain Integrin beta subunit, N-terminal

4 Cross Referencess

Identifier
PTHR10082
PIRSF002512
PR01186
PS00243

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

0 Proteins

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3028640
            2199285
            12297042
            14689578
            2467745
            12234368
            12361595