Protein Domain : IPR002035

Type:  Domain Name:  von Willebrand factor, type A
Description:  The von Willebrand factor is a large multimeric glycoprotein found in blood plasma. Mutant forms are involved in the aetiology of bleeding disorders []. In von Willebrand factor, the type A domain (vWF) is the prototype fora protein superfamily. The vWF domain is found in various plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular proteins [, , ]. Although the majority of VWA-containing proteins are extracellular, the most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription, DNA repair, ribosomal and membrane transport and the proteasome. A common feature appears to be involvement in multiprotein complexes. Proteinsthat incorporate vWF domains participate in numerous biological events (e.g. cell adhesion, migration, homing, pattern formation, and signaltransduction), involving interaction with a large array of ligands []. A number of human diseases arise from mutations in VWA domains. Secondary structure prediction from 75 aligned vWF sequences has revealed a largely alternating sequence of alpha-helices and beta-strands []. The vWF domain fold is predicted to be adoubly-wound, open, twisted beta-sheet flanked by alpha-helices []. 3D structures have been determined for the I-domains of integrins CD11b (with bound magnesium) [] and CD11a (with bound manganese) []. The domain adopts a classic alpha/beta Rossmann fold and contains an unusual metal ion coordination site at its surface. It has been suggested that this siterepresents a general metal ion-dependent adhesion site (MIDAS) for binding protein ligands []. The residues constituting the MIDAS motif in the CD11band CD11a I-domains are completely conserved, but the manner in which the metal ion is coordinated differs slightly []. Short Name:  VWF_A
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2 Child Features

DB identifier Type Name
IPR007198 Domain Ssl1-like
IPR025861 Domain Cobalamin biosynthesis protein CobT VWA domain

0 Contains

5 Cross Referencess

Identifier
PF00092
PS50234
SM00327
G3DSA:3.40.50.410
SSF53300

24 Found Ins

DB identifier Type Name
IPR011776 Family Magnesium chelatase, ATPase subunit D
IPR012170 Family TFIIH subunit Ssl1/p44
IPR011205 Family Uncharacterised conserved protein UCP015417, vWA
IPR012099 Family Midasin
IPR008912 Family Uncharacterised protein family CoxE-like
IPR006538 Family Cobalt chelatase, CobT subunit
IPR011360 Family Complement B/C2
IPR004727 Family Calcium-activated chloride channel protein
IPR017360 Family Anthrax toxin receptor
IPR017802 Family VWFA-related, acidobacterial-type
IPR022440 Family Conserved hypothetical protein CHP03788
IPR012011 Family von Willebrand factor
IPR016857 Family Uncharacterised conserved protein UCP027682, CUB, vWA
IPR010607 Family Protein of unknown function DUF1194
IPR011191 Family Uncharacterised protein family Treponema vWA
IPR011195 Family Uncharacterised conserved protein UCP010256
IPR011392 Family Tellurite resistance, TerY
IPR012013 Family Integrin beta-4 subunit
IPR014624 Family Predicted 26S proteasome regulatory complex, non-ATPase subcomplex, subunit s5a, Plasmodium
IPR015436 Family Integrin beta-6 subunit
IPR015439 Family Integrin beta-2 subunit
IPR012804 Family Cobaltochelatase subunit, putative
IPR015442 Family Integrin beta-8 subunit
IPR015812 Family Integrin beta subunit

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
170931 D8RF62 PAC:15409816 Selaginella moellendorffii 418  
92379 D8RFT8 PAC:15417730 Selaginella moellendorffii 173  
148275 D8RLF7 PAC:15406326 Selaginella moellendorffii 399  
165509 D8QUY9 PAC:15414214 Selaginella moellendorffii 564  
78255 D8QU89 PAC:15420050 Selaginella moellendorffii 565  
99409 D8RQN5 PAC:15416440 Selaginella moellendorffii 99  
174616 D8RVB1 PAC:15419185 Selaginella moellendorffii 720  
232450 D8RVB4 PAC:15419722 Selaginella moellendorffii 394  
141864 D8QWN5 PAC:15412794 Selaginella moellendorffii 412  
79941 D8QWH4 PAC:15405935 Selaginella moellendorffii 307  
107900 D8S3I7 PAC:15402145 Selaginella moellendorffii 763  
230282 D8QYY2 PAC:15412439 Selaginella moellendorffii 188  
444195 D8S7R7 PAC:15414574 Selaginella moellendorffii 549  
38056 D8SAN8 PAC:15412066 Selaginella moellendorffii 55  
419836 D8SAP6 PAC:15412729 Selaginella moellendorffii 1354  
444452 D8SAP2 PAC:15416656 Selaginella moellendorffii 550  
420109 D8SB01 PAC:15410539 Selaginella moellendorffii 646  
112999 D8SB02 PAC:15417273 Selaginella moellendorffii 642  
421953 D8SGW3 PAC:15419663 Selaginella moellendorffii 2190  
423099 D8SKK2 PAC:15418733 Selaginella moellendorffii 843  
445701 D8SKK5 PAC:15421669 Selaginella moellendorffii 449  
423699 D8SML3 PAC:15423202 Selaginella moellendorffii 609  
168140 D8R5T0 PAC:15419910 Selaginella moellendorffii 756  
157789 D8SRY9 PAC:15414599 Selaginella moellendorffii 898  
402207 D8QPX5 PAC:15402645 Selaginella moellendorffii 563  
402200 D8QPW8 PAC:15402638 Selaginella moellendorffii 686  
402199 D8QPW7 PAC:15402147 Selaginella moellendorffii 878  
402202 D8QPX0 PAC:15402641 Selaginella moellendorffii 545  
402201 D8QPW9 PAC:15402640 Selaginella moellendorffii 788  
402429 D8QQL6 PAC:15404191 Selaginella moellendorffii 2174  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1864378
            8145250
            8412987
            7867070
            8440408
            7843416
            7479767