Protein Domain : IPR012011

Type:  Family Name:  von Willebrand factor
Description:  von Willebrand factor (vWF) is a multimeric adhesive protein that plays a key role in platelet function by mediating the initiation and progression of thrombus formation at sites of vascular injury []. Binding of vWF to platelet membrane glycoprotein GPIb-alpha () of the GPIb-IX-V complex supports the arrest of bleeding after tissue trauma. The rapid association of GP1b-alpha with vWF not only initiates platelet deposition at the sites of vascular injury but is essential for maintaining thrombus growth in blood flowing at high shear rates. Short Name:  VWF
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0 Child Features

5 Contains

DB identifier Type Name
IPR002035 Domain von Willebrand factor, type A
IPR002919 Domain Trypsin Inhibitor-like, cysteine rich domain
IPR001846 Domain von Willebrand factor, type D domain
IPR006207 Domain Cystine knot, C-terminal
IPR001007 Domain VWFC domain

1 Cross References

Identifier
PTHR11339:SF259

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0007155 IPR012011
GO:0007596 IPR012011
GO:0005578 IPR012011

3 Ontology Annotations

GO Term Gene Name
GO:0007155 IPR012011
GO:0007596 IPR012011
GO:0005578 IPR012011

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12871266