Protein Domain : IPR002049

Type:  Domain Name:  Laminin EGF domain
Description:  Laminins [] are the major noncollagenous components of basement membranesthat mediate cell adhesion, growth migration, and differentiation. They are composed of distinct but related alpha, beta and gamma chains. The threechains form a cross-shaped molecule that consist of a long arm and three short globular arms. The long arm consist of a coiled coil structure contributed byall three chains and cross-linked by interchain disulphide bonds. Beside different types of globular domains each subunit contains, in its firsthalf, consecutive repeats of about 60 amino acids in length that include eight conserved cysteines []. The tertiary structure [, ] of this domain isremotely similar in its N-terminal to that of the EGF-like module (see ). It is known as a 'LE' or 'laminin-type EGF-like' domain. The number of copies of the LE domain in the different forms of laminins is highlyvariable; from 3 up to 22 copies have been found. A schematic representation of the topology of the four disulphide bonds inthe LE domain is shown below. +-------------------+ +-|-----------+ | +--------+ +-----------------+| | | | | | | | xxCxCxxxxxxxxxxxCxxxxxxxCxxCxxxxxGxxCxxCxxgaagxxxxxxxxxxxCxxsssssssssssssssssssssssssssssssssss 'C': conserved cysteine involved in a disulphide bond'a': conserved aromatic residue 'G': conserved glycine (lower case = less conserved)'s': region similar to the EGF-like domain In mouse laminin gamma-1 chain, the seventh LE domain has been shown to be the only one that binds with a high affinity to nidogen []. The binding-sites arelocated on the surface within the loops C1-C3 and C5-C6 [, ]. Longconsecutive arrays of LE domains in laminins form rod-like elements of limited flexibility [], which determine the spacing in the formation of lamininnetworks of basement membranes []. Short Name:  Laminin_EGF
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0 Child Features

2 Contains

DB identifier Type Name
IPR000742 Domain EGF-like domain
IPR013032 Conserved_site EGF-like, conserved site

4 Cross Referencess

Identifier
PF00053
PS01248
PS50027
SM00180

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
40737 A4S8I9 PAC:27417251 Ostreococcus lucimarinus 172  
Cre10.g437300.t1.1 A0A2K3DA98 PAC:30790333 Chlamydomonas reinhardtii 4089  
Mapoly0050s0101.2.p A0A2R6WXS9 PAC:33006226 Marchantia polymorpha 1516  
Mapoly0050s0101.1.p A0A2R6WXS5 PAC:33006225 Marchantia polymorpha 1604  
Nycol.O01127.1.p PAC:44520205 Nymphaea colorata 1539  
Vocar.0001s1328.1.p PAC:32885266 Volvox carteri 3297  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2404817
            2666164
            7781764
            8349613
            8648630
            8648631