Protein Domain : IPR008294

Type:  Family Name:  Meprin alpha/beta subunit
Description:  This family contains the alpha and beta subunits of meprin. Meprins are metazoan zinc metallopeptidases belonging to MEROPS peptidase family M12 (clan MA(M)), subfamily M12A (astacin family). They are complex and structurally unique homo- or heterotetrameric glycoproteins composed of evolutionarily related alpha and/or beta subunits that contain disulphide-bridged dimers. The two subunits are differentially expressed and processed to yield latent and active proteases as well as membrane-associated and secreted forms. They are excellent models of homo- and hetero-oligomeric enzymes that are regulated at the transcriptional and post translational levels []. Each chain contains an astacin domain, MAM, MATH, and AM (after MATH) domains [], and an EGF-like domain.The astacin domain is a Zn-metalloprotease domain characterised by a unique 18-amino acid signature sequence, HEXXHXXGFXHEXXRXDR [], which begins with the zinc binding motif HEXXH. The MAM domain is necessary for correct folding and transport through the secretory pathway. The MATH domain is required for folding of an activatable zymogen, and the AM domain is important for activity against proteins and efficient secretion of the protein. Meprin is able to cleave a variety of substrates and has a role in matrix remodeling, inflammation, and cell-cell and cell-matrix processes []. Known substrates include FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10 and tenascin-C []. Short Name:  Meprin
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0 Child Features

5 Contains

DB identifier Type Name
IPR002083 Domain MATH/TRAF domain
IPR000742 Domain EGF-like domain
IPR006026 Domain Peptidase, metallopeptidase
IPR000998 Domain MAM domain
IPR001506 Domain Peptidase M12A, astacin

3 Cross Referencess

Identifier
PTHR10127:SF311
PTHR10127:SF312
PIRSF001196

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004222 IPR008294
GO:0008270 IPR008294
GO:0006508 IPR008294
GO:0016020 IPR008294

4 Ontology Annotations

GO Term Gene Name
GO:0004222 IPR008294
GO:0008270 IPR008294
GO:0006508 IPR008294
GO:0016020 IPR008294

0 Parent Features

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8387703
            9857066
            7670368
            23427141
            21693781