Protein Domain : IPR015421

Type:  Domain Name:  Pyridoxal phosphate-dependent transferase, major region, subdomain 1
Description:  Pyridoxal phosphate is the active form of vitamin B6 (pyridoxine or pyridoxal). Pyridoxal 5'-phosphate (PLP) is a versatile catalyst, acting as a coenzyme in a multitude of reactions, including decarboxylation, deamination and transamination [, , ]. PLP-dependent enzymes are primarily involved in the biosynthesis of amino acids and amino acid-derived metabolites, but they are also found in the biosynthetic pathways of amino sugars and in the synthesis or catabolism of neurotransmitters; pyridoxal phosphate can also inhibit DNA polymerases and several steroid receptors []. Inadequate levels of pyridoxal phosphate in the brain can cause neurological dysfunction, particularly epilepsy [].PLP enzymes exist in their resting state as a Schiff base, the aldehyde group of PLP forming a linkage with the epsilon-amino group of an active site lysine residue on the enzyme. The alpha-amino group of the substrate displaces the lysine epsilon-amino group, in the process forming a new aldimine with the substrate. This aldimine is the common central intermediate for all PLP-catalysed reactions, enzymatic and non-enzymatic [].This entry represents subdomain 1 of the major region of PLP-dependent transferases. This domain has a 3-layer alpha/beta/alpha sandwich topology. The major region can be found in the following PLP-dependent transferase families:Aspartate aminotransferase (AAT)-like enzymes, such as aromatic aminoacid aminotransferase AroAT, glutamine aminotransferase and kynureninase [].Beta-eliminating lyases, such as tyrosine phenol lyase and tryptophanase [].Pyridoxal-dependent decarboxylases, such as DOPA decarboxylase and glutamate decarboxylase beta (GadB) [].Cystathionine synthase-like enzymes, such as cystalysin, methionine gamma-lyase (MGL), and cysteine desulphurase (IscS) [].GABA-aminotransferase-like enzymes, such as ornithine aminotransferase and serine hydroxymethyltransferase [].Ornithine decarboxylase major domain []. Short Name:  PyrdxlP-dep_Trfase_major_sub1
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0 Child Features

6 Contains

DB identifier Type Name
IPR020578 Binding_site Aminotransferase class-V, pyridoxal-phosphate binding site
IPR021115 Binding_site Pyridoxal-phosphate binding site
IPR004838 Binding_site Aminotransferases, class-I, pyridoxal-phosphate-binding site
IPR001917 Binding_site Aminotransferase, class-II, pyridoxal-phosphate binding site
IPR019798 Binding_site Serine hydroxymethyltransferase, pyridoxal phosphate binding site
IPR018176 Conserved_site Tryptophanase, conserved site

1 Cross References

Identifier
G3DSA:3.40.640.10

74 Found Ins

DB identifier Type Name
IPR003437 Family Glycine dehydrogenase (decarboxylating)
IPR020580 Domain Glycine cleavage system P-protein, N-terminal
IPR020581 Family Glycine cleavage system P protein
IPR010970 Family Cysteine desulfurase, SufS
IPR005861 Family Histidinol-phosphate aminotransferase family
IPR004639 Family Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase
IPR015424 Domain Pyridoxal phosphate-dependent transferase
IPR002129 Family Pyridoxal phosphate-dependent decarboxylase
IPR004839 Domain Aminotransferase, class I/classII
IPR006948 Domain Alliinase, C-terminal
IPR010107 Family Glutamate decarboxylase
IPR000277 Family Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
IPR000796 Family Aspartate/other aminotransferase
IPR005814 Family Aminotransferase class-III
IPR010164 Family Ornithine aminotransferase
IPR010977 Family Aromatic-L-amino-acid decarboxylase
IPR004636 Family Acetylornithine/Succinylornithine transaminase family
IPR001085 Family Serine hydroxymethyltransferase
IPR000192 Domain Aminotransferase class V domain
IPR022278 Family Phosphoserine aminotransferase
IPR001597 Domain Aromatic amino acid beta-eliminating lyase/threonine aldolase
IPR006238 Family Cystathionine beta-lyase, eukaryotic
IPR016454 Family Cysteine desulfurase
IPR010240 Family Cysteine desulfurase IscS
IPR019942 Family LL-diaminopimelate aminotransferase, plants and Chlamydia type
IPR000653 Family DegT/DnrJ/EryC1/StrS aminotransferase
IPR008829 Family SepSecS/SepCysS family
IPR005958 Family Tyrosine/nicotianamine aminotransferase
IPR000310 Domain Orn/Lys/Arg decarboxylase, major domain
IPR022518 Family Aspartate 4-decarboxylase

1 GO Annotation

GO Term Gene Name
GO:0003824 IPR015421

1 Ontology Annotations

GO Term Gene Name
GO:0003824 IPR015421

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
411297 D8RH71 PAC:15407090 Selaginella moellendorffii 180  
94437 D8RIJ8 PAC:15401918 Selaginella moellendorffii 460  
411952 D8RJJ8 PAC:15412496 Selaginella moellendorffii 241  
30531 D8RLL2 PAC:15414847 Selaginella moellendorffii 906  
412499 D8RLN9 PAC:15411699 Selaginella moellendorffii 424  
96710 D8RM78 PAC:15410029 Selaginella moellendorffii 281  
173087 D8RP46 PAC:15411876 Selaginella moellendorffii 410  
413459 D8RPJ0 PAC:15414595 Selaginella moellendorffii 767  
232064 D8RPZ5 PAC:15416655 Selaginella moellendorffii 421  
413706 D8RPZ0 PAC:15416636 Selaginella moellendorffii 412  
173967 D8RSX4 PAC:15418687 Selaginella moellendorffii 458  
438442 D8QY48 PAC:15421071 Selaginella moellendorffii 289  
416810 D8S0H2 PAC:15403763 Selaginella moellendorffii 520  
38995 D8SD40 PAC:15419090 Selaginella moellendorffii 64  
59797 D8SEM9 PAC:15412551 Selaginella moellendorffii 101  
139046 D8TGJ1 PAC:15422745 Selaginella moellendorffii 141  
407822 D8R4V5 PAC:15421882 Selaginella moellendorffii 418  
402494 D8QQU4 PAC:15404336 Selaginella moellendorffii 421  
402512 D8QQW6 PAC:15404929 Selaginella moellendorffii 593  
184818 D8T2G8 PAC:15405524 Selaginella moellendorffii 413  
408231 D8R7M1 PAC:15420325 Selaginella moellendorffii 157  
403841 D8QSQ2 PAC:15410369 Selaginella moellendorffii 250  
403682 D8QS70 PAC:15408833 Selaginella moellendorffii 415  
439888 D8R817 PAC:15404798 Selaginella moellendorffii 591  
427112 D8SYJ5 PAC:15408593 Selaginella moellendorffii 115  
270727 D8RC09 PAC:15422483 Selaginella moellendorffii 522  
427104 D8SYI7 PAC:15408569 Selaginella moellendorffii 145  
evm.TU.contig_37718.1 PAC:16431066 Carica papaya 248  
evm.model.supercontig_0.44 PAC:16403949 Carica papaya 43  
evm.model.supercontig_113.61 PAC:16406074 Carica papaya 147  

12 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7748903
            15581583
            8690703
            15189147
            16763894
            17109392
            10666573
            17300176
            16790938
            15690345
            17014820
            15848278