Protein Domain : IPR004838

Type:  Binding_site Name:  Aminotransferases, class-I, pyridoxal-phosphate-binding site
Description:  Pyridoxal phosphate is the active form of vitamin B6 (pyridoxine or pyridoxal). Pyridoxal 5'-phosphate (PLP) is a versatile catalyst, acting as a coenzyme in a multitude of reactions, including decarboxylation, deamination and transamination [, , ]. PLP-dependent enzymes are primarily involved in the biosynthesis of amino acids and amino acid-derived metabolites, but they are also found in the biosynthetic pathways of amino sugars and in the synthesis or catabolism of neurotransmitters; pyridoxal phosphate can also inhibit DNA polymerases and several steroid receptors []. Inadequate levels of pyridoxal phosphate in the brain can cause neurological dysfunction, particularly epilepsy [].PLP enzymes exist in their resting state as a Schiff base, the aldehyde group of PLP forming a linkage with the epsilon-amino group of an active site lysine residue on the enzyme. The alpha-amino group of the substrate displaces the lysine epsilon-amino group, in the process forming a new aldimine with the substrate. This aldimine is the common central intermediate for all PLP-catalysed reactions, enzymatic and non-enzymatic [].Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes, such as the covalent binding of the pyridoxal-phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped [] into subfamilies; these sequences are defined by the aminotransferases class-I pyridoxal-phosphate attachment site signature, which contains the lysine residue involved in pyridoxal-phosphate binding. Short Name:  NHTrfase_class1_PyrdxlP-BS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00105

9 Found Ins

DB identifier Type Name
IPR015424 Domain Pyridoxal phosphate-dependent transferase
IPR015421 Domain Pyridoxal phosphate-dependent transferase, major region, subdomain 1
IPR004839 Domain Aminotransferase, class I/classII
IPR000796 Family Aspartate/other aminotransferase
IPR022518 Family Aspartate 4-decarboxylase
IPR005860 Family L-threonine-O-3-phosphate decarboxylase
IPR005957 Family Tyrosine aminotransferase
IPR019880 Family Succinyldiaminopimelate transaminase, DapC, actinobacteria
IPR019881 Family Diaminopimelate aminotransferase, DapL, Desulfovibrio-type

3 GO Annotations

GO Term Gene Name
GO:0003824 IPR004838
GO:0030170 IPR004838
GO:0009058 IPR004838

3 Ontology Annotations

GO Term Gene Name
GO:0003824 IPR004838
GO:0030170 IPR004838
GO:0009058 IPR004838

0 Parent Features

0 Proteins

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7748903
            15581583
            8690703
            15189147
            16763894
            17109392
            1990006