Protein Domain : IPR015424

Type:  Domain Name:  Pyridoxal phosphate-dependent transferase
Description:  Pyridoxal phosphate is the active form of vitamin B6 (pyridoxine or pyridoxal). Pyridoxal 5'-phosphate (PLP) is a versatile catalyst, acting as a coenzyme in a multitude of reactions, including decarboxylation, deamination and transamination [, , ]. PLP-dependent enzymes are primarily involved in the biosynthesis of amino acids and amino acid-derived metabolites, but they are also found in the biosynthetic pathways of amino sugars and in the synthesis or catabolism of neurotransmitters; pyridoxal phosphate can also inhibit DNA polymerases and several steroid receptors []. Inadequate levels of pyridoxal phosphate in the brain can cause neurological dysfunction, particularly epilepsy [].PLP enzymes exist in their resting state as a Schiff base, the aldehyde group of PLP forming a linkage with the epsilon-amino group of an active site lysine residue on the enzyme. The alpha-amino group of the substrate displaces the lysine epsilon-amino group, in the process forming a new aldimine with the substrate. This aldimine is the common central intermediate for all PLP-catalysed reactions, enzymatic and non-enzymatic [].This entry represents the major region of PLP-dependent transferases. This domain has a three layer alpha/beta/alpha sandwich topology, with mixed beta-sheets of 7 strands. The major region can be found in the following PLP-dependent transferase families:Aspartate aminotransferase (AAT)-like enzymes, such as aromatic aminoacid aminotransferase AroAT, glutamine aminotransferase and kynureninase [].Beta-eliminating lyases, such as tyrosine phenol lyase and tryptophanase [].Pyridoxal-dependent decarboxylases, such as DOPA decarboxylase and glutamate decarboxylase beta (GadB) [].Cystathionine synthase-like enzymes, such as cystalysin, methionine gamma-lyase (MGL), and cysteine desulphurase (IscS) [].GABA-aminotransferase-like enzymes, such as ornithine aminotransferase and serine hydroxymethyltransferase [].Ornithine decarboxylase major domain []. Short Name:  PyrdxlP-dep_Trfase
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6 Child Features

DB identifier Type Name
IPR020580 Domain Glycine cleavage system P-protein, N-terminal
IPR004839 Domain Aminotransferase, class I/classII
IPR006948 Domain Alliinase, C-terminal
IPR000192 Domain Aminotransferase class V domain
IPR001597 Domain Aromatic amino acid beta-eliminating lyase/threonine aldolase
IPR000310 Domain Orn/Lys/Arg decarboxylase, major domain

9 Contains

DB identifier Type Name
IPR015421 Domain Pyridoxal phosphate-dependent transferase, major region, subdomain 1
IPR015422 Domain Pyridoxal phosphate-dependent transferase, major region, subdomain 2
IPR006947 Domain EGF-like, alliinase
IPR020578 Binding_site Aminotransferase class-V, pyridoxal-phosphate binding site
IPR021115 Binding_site Pyridoxal-phosphate binding site
IPR004838 Binding_site Aminotransferases, class-I, pyridoxal-phosphate-binding site
IPR001917 Binding_site Aminotransferase, class-II, pyridoxal-phosphate binding site
IPR019798 Binding_site Serine hydroxymethyltransferase, pyridoxal phosphate binding site
IPR018176 Conserved_site Tryptophanase, conserved site

1 Cross References

Identifier
SSF53383

2 Found Ins

DB identifier Type Name
IPR003437 Family Glycine dehydrogenase (decarboxylating)
IPR020581 Family Glycine cleavage system P protein

0 GO Annotation

0 Ontology Annotations

0 Parent Features

45262 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
92159 D8RFJ5 PAC:15416176 Selaginella moellendorffii 470  
171289 D8RHM3 PAC:15407399 Selaginella moellendorffii 359  
270846 D8RGS2 PAC:15423279 Selaginella moellendorffii 463  
94437 D8RIJ8 PAC:15401918 Selaginella moellendorffii 460  
411952 D8RJJ8 PAC:15412496 Selaginella moellendorffii 241  
412499 D8RLN9 PAC:15411699 Selaginella moellendorffii 424  
97066 D8RMD7 PAC:15407573 Selaginella moellendorffii 481  
230105 D8QUP1 PAC:15411495 Selaginella moellendorffii 469  
79134 D8QUY4 PAC:15422028 Selaginella moellendorffii 517  
78872 D8QU94 PAC:15402317 Selaginella moellendorffii 419  
173087 D8RP46 PAC:15411876 Selaginella moellendorffii 410  
232016 D8RPG2 PAC:15416505 Selaginella moellendorffii 447  
232064 D8RPZ5 PAC:15416655 Selaginella moellendorffii 421  
413615 D8RQV0 PAC:15415962 Selaginella moellendorffii 849  
413706 D8RPZ0 PAC:15416636 Selaginella moellendorffii 412  
99781 D8RR26 PAC:15418978 Selaginella moellendorffii 358  
173762 D8RS51 PAC:15417140 Selaginella moellendorffii 831  
165967 D8QY45 PAC:15417311 Selaginella moellendorffii 397  
62381 D8QX99 PAC:15418461 Selaginella moellendorffii 505  
175502 D8RYU7 PAC:15421214 Selaginella moellendorffii 472  
105841 D8S0K7 PAC:15417944 Selaginella moellendorffii 409  
416810 D8S0H2 PAC:15403763 Selaginella moellendorffii 520  
138766 D8TG05 PAC:15402895 Selaginella moellendorffii 180  
444047 D8S6V4 PAC:15413646 Selaginella moellendorffii 480  
166496 D8QYX4 PAC:15416451 Selaginella moellendorffii 470  
230362 D8QZT7 PAC:15413183 Selaginella moellendorffii 394  
111238 D8S929 PAC:15408798 Selaginella moellendorffii 588  
111492 D8S939 PAC:15410567 Selaginella moellendorffii 588  
111484 D8S925 PAC:15410541 Selaginella moellendorffii 588  
111512 D8S927 PAC:15411172 Selaginella moellendorffii 588  

12 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7748903
            15581583
            8690703
            15189147
            16763894
            17109392
            10666573
            17300176
            16790938
            15690345
            17014820
            15848278