Protein Domain : IPR003437

Type:  Family Name:  Glycine dehydrogenase (decarboxylating)
Description:  The P protein is part of the glycine decarboxylase multienzyme complex (GDC), also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T []. The P protein () binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor, carbon dioxide is released and the remaining methylamin moiety is then transferred to the lipoamide cofactor of the H protein. The reaction catalysed by this protein is:Glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2 The subunit composition of glycine cleavage system P proteins have been classified into two types. Those from eukaryotes and some of the P proteins from prokaryotes (e.g. Escherichia coli) are in the homodimeric form. The rest of those from prokaryotes are heterotetrameric, with two different subunits which, based on sequence similarities, correspond respectively to the N and C-terminal halves of the eukaryotic subunit [].This entry represents the P protein homodimeric subfamily, which is found in eukaryotes and some prokaryotes, such as E. coli. Short Name:  GcvP
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0 Child Features

3 Contains

DB identifier Type Name
IPR020580 Domain Glycine cleavage system P-protein, N-terminal
IPR015424 Domain Pyridoxal phosphate-dependent transferase
IPR015421 Domain Pyridoxal phosphate-dependent transferase, major region, subdomain 1

2 Cross Referencess

Identifier
TIGR00461
MF_00711

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004375 IPR003437
GO:0006544 IPR003437
GO:0055114 IPR003437

3 Ontology Annotations

GO Term Gene Name
GO:0004375 IPR003437
GO:0006544 IPR003437
GO:0055114 IPR003437

1 Parent Features

DB identifier Type Name
IPR020581 Family Glycine cleavage system P protein

550 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
153563 D8S913 PAC:15423428 Selaginella moellendorffii 946  
evm.model.supercontig_7.178 PAC:16425084 Carica papaya 963  
29794.m003324 B9RRS7 PAC:16808685 Ricinus communis 1057  
Cucsa.395120.1 PAC:16983305 Cucumis sativus 1047  
orange1.1g001531m A0A067GXA5 PAC:18096521 Citrus sinensis 1058  
orange1.1g001579m A0A067GKC4 PAC:18096523 Citrus sinensis 1050  
orange1.1g001533m A0A067GXA5 PAC:18096522 Citrus sinensis 1058  
orange1.1g001586m A0A067GN34 PAC:18096524 Citrus sinensis 1049  
orange1.1g001769m A0A067GN27 PAC:18096525 Citrus sinensis 1016  
orange1.1g002263m A0A067GK35 PAC:18096528 Citrus sinensis 946  
orange1.1g001989m A0A067GXN8 PAC:18096526 Citrus sinensis 985  
orange1.1g001990m A0A067GXB1 PAC:18096527 Citrus sinensis 985  
AT4G33010.2 B3H5Y8 PAC:19644017 Arabidopsis thaliana 976  
AT4G33010.1 Q94B78 PAC:19644016 Arabidopsis thaliana 1037  
AT2G26080.1 O80988 PAC:19639459 Arabidopsis thaliana 1044  
Thhalv10024257m V4MBS0 PAC:20192769 Eutrema salsugineum 1146  
Thhalv10001891m V4M2B6 PAC:20200623 Eutrema salsugineum 1041  
Ciclev10007310m V4WCA9 PAC:20794460 Citrus clementina 1058  
Lus10024989 PAC:23148402 Linum usitatissimum 1062  
Potri.006G229300.11 PAC:27003802 Populus trichocarpa 806  
Potri.006G229300.4 PAC:27003799 Populus trichocarpa 987  
Potri.006G229300.10 PAC:27003801 Populus trichocarpa 832  
Potri.006G229300.8 PAC:27003796 Populus trichocarpa 1042  
Potri.006G229300.1 B9HDN2 PAC:27003794 Populus trichocarpa 1060  
Potri.006G229300.5 PAC:27003800 Populus trichocarpa 981  
Potri.006G229300.3 PAC:27003803 Populus trichocarpa 800  
Potri.006G229300.2 PAC:27003804 Populus trichocarpa 728  
Potri.006G229300.6 PAC:27003798 Populus trichocarpa 998  
Potri.006G229300.7 PAC:27003797 Populus trichocarpa 998  
Potri.006G229300.9 PAC:27003795 Populus trichocarpa 1054  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8181752
            15791207