Protein Domain : IPR015422

Type:  Domain Name:  Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Description:  Pyridoxal phosphate is the active form of vitamin B6 (pyridoxine or pyridoxal). Pyridoxal 5'-phosphate (PLP) is a versatile catalyst, acting as a coenzyme in a multitude of reactions, including decarboxylation, deamination and transamination [, , ]. PLP-dependent enzymes are primarily involved in the biosynthesis of amino acids and amino acid-derived metabolites, but they are also found in the biosynthetic pathways of amino sugars and in the synthesis or catabolism of neurotransmitters; pyridoxal phosphate can also inhibit DNA polymerases and several steroid receptors []. Inadequate levels of pyridoxal phosphate in the brain can cause neurological dysfunction, particularly epilepsy [].PLP enzymes exist in their resting state as a Schiff base, the aldehyde group of PLP forming a linkage with the epsilon-amino group of an active site lysine residue on the enzyme. The alpha-amino group of the substrate displaces the lysine epsilon-amino group, in the process forming a new aldimine with the substrate. This aldimine is the common central intermediate for all PLP-catalysed reactions, enzymatic and non-enzymatic [].This entry represents subdomain 2 of the major region of PLP-dependent transferases. This domain has a complex alpha/beta structure. The major region can be found in the following PLP-dependent transferase families:Aspartate aminotransferase (AAT)-like enzymes, such as aromatic aminoacid aminotransferase AroAT, glutamine aminotransferase and kynureninase [].Beta-eliminating lyases, such as tyrosine phenol lyase and tryptophanase [].Pyridoxal-dependent decarboxylases, such as DOPA decarboxylase and glutamate decarboxylase beta (GadB) [].Cystathionine synthase-like enzymes, such as cystalysin, methionine gamma-lyase (MGL), and cysteine desulphurase (IscS) [].GABA-aminotransferase-like enzymes, such as ornithine aminotransferase and serine hydroxymethyltransferase [].Ornithine decarboxylase major domain []. Short Name:  PyrdxlP-dep_Trfase_major_sub2
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0 Child Features

0 Contains

1 Cross References

Identifier
G3DSA:3.90.1150.10

20 Found Ins

DB identifier Type Name
IPR015424 Domain Pyridoxal phosphate-dependent transferase
IPR002129 Family Pyridoxal phosphate-dependent decarboxylase
IPR006948 Domain Alliinase, C-terminal
IPR000277 Family Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
IPR022278 Family Phosphoserine aminotransferase
IPR006238 Family Cystathionine beta-lyase, eukaryotic
IPR019942 Family LL-diaminopimelate aminotransferase, plants and Chlamydia type
IPR000653 Family DegT/DnrJ/EryC1/StrS aminotransferase
IPR000310 Domain Orn/Lys/Arg decarboxylase, major domain
IPR006235 Family O-acetylhomoserine/O-acetylserine sulfhydrylase
IPR011821 Family O-succinylhomoserine (thiol)-lyase
IPR006233 Family Cystathionine beta-lyase, bacterial
IPR006234 Family O-succinylhomoserine sulfhydrylase
IPR006237 Family Methionine gamma-lyase
IPR012749 Family TDP-4-keto-6-deoxy-D-glucose transaminase
IPR005860 Family L-threonine-O-3-phosphate decarboxylase
IPR019881 Family Diaminopimelate aminotransferase, DapL, Desulfovibrio-type
IPR011193 Family Ornithine/lysine/arginine decarboxylase
IPR020026 Family UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase
IPR022517 Family Aspartate 1-decarboxylase, pyridoxal-dependent

1 GO Annotation

GO Term Gene Name
GO:0003824 IPR015422

1 Ontology Annotations

GO Term Gene Name
GO:0003824 IPR015422

0 Parent Features

40233 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
92159 D8RFJ5 PAC:15416176 Selaginella moellendorffii 470  
171289 D8RHM3 PAC:15407399 Selaginella moellendorffii 359  
270846 D8RGS2 PAC:15423279 Selaginella moellendorffii 463  
230105 D8QUP1 PAC:15411495 Selaginella moellendorffii 469  
404623 D8QVW8 PAC:15411713 Selaginella moellendorffii 953  
79134 D8QUY4 PAC:15422028 Selaginella moellendorffii 517  
79052 D8QUJ0 PAC:15421332 Selaginella moellendorffii 652  
78872 D8QU94 PAC:15402317 Selaginella moellendorffii 419  
232016 D8RPG2 PAC:15416505 Selaginella moellendorffii 447  
98495 D8RNP0 PAC:15413842 Selaginella moellendorffii 850  
413615 D8RQV0 PAC:15415962 Selaginella moellendorffii 849  
173762 D8RS51 PAC:15417140 Selaginella moellendorffii 831  
415080 D8RUY5 PAC:15417334 Selaginella moellendorffii 868  
165967 D8QY45 PAC:15417311 Selaginella moellendorffii 397  
62381 D8QX99 PAC:15418461 Selaginella moellendorffii 505  
175502 D8RYU7 PAC:15421214 Selaginella moellendorffii 472  
105841 D8S0K7 PAC:15417944 Selaginella moellendorffii 409  
444047 D8S6V4 PAC:15413646 Selaginella moellendorffii 480  
166496 D8QYX4 PAC:15416451 Selaginella moellendorffii 470  
230362 D8QZT7 PAC:15413183 Selaginella moellendorffii 394  
111238 D8S929 PAC:15408798 Selaginella moellendorffii 588  
111492 D8S939 PAC:15410567 Selaginella moellendorffii 588  
111484 D8S925 PAC:15410541 Selaginella moellendorffii 588  
111358 D8S923 PAC:15409648 Selaginella moellendorffii 588  
154248 D8SCG2 PAC:15401773 Selaginella moellendorffii 409  
143081 D8R0S3 PAC:15412589 Selaginella moellendorffii 437  
432609 D8TGJ0 PAC:15404951 Selaginella moellendorffii 109  
228964 D8SK20 PAC:15411621 Selaginella moellendorffii 401  
143363 D8R3J6 PAC:15414888 Selaginella moellendorffii 466  
143343 D8R3H0 PAC:15414840 Selaginella moellendorffii 388  

12 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7748903
            15581583
            8690703
            15189147
            16763894
            17109392
            10666573
            17300176
            16790938
            15690345
            17014820
            15848278