Protein Domain : IPR011193

Type:  Family Name:  Ornithine/lysine/arginine decarboxylase
Description:  This family is composed of ornithine decarboxylases (ODC), arginine decarboxylases (ADC) and lysine decarboxylases (LDC), and belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase domainsuperfamily (fold I) []. These enzymes catalyse the decarboxylation of ornithine,arginine, or lysine, respectively using PLP as a co-factor. ODC is active as a dimer and catalyses the decarboxylation of tryptophan []. ADC catalyses the decarboxylation of arginine and LDCcatalyses the decarboxylation of lysine. The PLP combines with the alpha-amino acid to form a Schiff base, which acts as the substrate in the decarboxylation (COOH group removal) reaction [].Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction theycatalysed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not alwaysagree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartateaminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), D-amino acid superfamily (fold type IV) and glycogen phophorylase family(fold type V) [, ].For additional information please see [, ]. Short Name:  Orn/lys/arg_de-COase
Paste the following link

2 Child Features

DB identifier Type Name
IPR027605 Family Putative ornithine decarboxylase, Lactobacillus
IPR027568 Family Ornithine decarboxylase SpeF

6 Contains

DB identifier Type Name
IPR011006 Domain CheY-like superfamily
IPR015421 Domain Pyridoxal phosphate-dependent transferase, major region, subdomain 1
IPR015422 Domain Pyridoxal phosphate-dependent transferase, major region, subdomain 2
IPR008286 Domain Orn/Lys/Arg decarboxylase, C-terminal
IPR000310 Domain Orn/Lys/Arg decarboxylase, major domain
IPR005308 Domain Orn/Lys/Arg decarboxylase, N-terminal

1 Cross References

Identifier
PIRSF009393

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0016831 IPR011193
GO:0006520 IPR011193
GO:0005737 IPR011193

3 Ontology Annotations

GO Term Gene Name
GO:0016831 IPR011193
GO:0006520 IPR011193
GO:0005737 IPR011193

0 Parent Features

0 Proteins

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8181483
            7748903
            8112347
            7663340
            9405048
            9063963
            7961515