Protein Domain : IPR001085

Type:  Family Name:  Serine hydroxymethyltransferase
Description:  This entry includes serine hydroxymethyltransferases, fluorothreonine transaldolases and other uncharacterised proteins. Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate (PLP) dependent enzyme and belongs to the aspartate aminotransferase superfamily (fold type I) []. The pyridoxal-P group is attached to a lysine residue around which the sequence is highly conserved in all forms of the enzyme []. The enzyme carries out interconversion of serine and glycine using PLP as the cofactor. SHMT catalyses the transfer of a hydroxymethyl group from N5, N10- methylene tetrahydrofolate to glycine, resulting in the formation of serine and tetrahydrofolate. Both eukaryotic and prokaryotic SHMT enzymes form tight obligate homodimers and the mammalian enzyme forms a homotetramer [, ]. Short Name:  Ser_HO-MeTrfase
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1 Child Features

DB identifier Type Name
IPR030979 Family Fluorothreonine transaldolase

2 Contains

DB identifier Type Name
IPR015421 Domain Pyridoxal phosphate-dependent transferase, major region, subdomain 1
IPR019798 Binding_site Serine hydroxymethyltransferase, pyridoxal phosphate binding site

4 Cross Referencess

Identifier
PTHR11680
PF00464
PIRSF000412
MF_00051

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0016740 IPR001085

1 Ontology Annotations

GO Term Gene Name
GO:0016740 IPR001085

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
232016 D8RPG2 PAC:15416505 Selaginella moellendorffii 447  
166496 D8QYX4 PAC:15416451 Selaginella moellendorffii 470  
270566 D8R648 PAC:15421045 Selaginella moellendorffii 533  
90314 D8RC81 PAC:15411772 Selaginella moellendorffii 505  
evm.model.supercontig_129.14 PAC:16407514 Carica papaya 518  
evm.model.supercontig_157.47 PAC:16409835 Carica papaya 471  
evm.model.supercontig_177.6 PAC:16411127 Carica papaya 392  
evm.model.supercontig_30.43 PAC:16416992 Carica papaya 317  
evm.model.supercontig_49.118 PAC:16421029 Carica papaya 583  
29908.m005955 B9RJC7 PAC:16812779 Ricinus communis 567  
29596.m000695 B9SMX7 PAC:16803392 Ricinus communis 513  
29629.m001438 B9S9Y7 PAC:16804017 Ricinus communis 471  
29222.m000393 B9SU62 PAC:16802496 Ricinus communis 590  
28333.m000569 B9SMK7 PAC:16800683 Ricinus communis 515  
Cucsa.103800.1 A0A0A0KLP6 PAC:16959096 Cucumis sativus 519  
Cucsa.032990.1 A0A0A0LAD1 PAC:16952513 Cucumis sativus 585  
Cucsa.064420.1 PAC:16955018 Cucumis sativus 536  
Cucsa.160810.1 PAC:16965411 Cucumis sativus 516  
Cucsa.179980.5 PAC:16967262 Cucumis sativus 463  
Cucsa.179980.6 PAC:16967263 Cucumis sativus 419  
Cucsa.179980.2 A0A0A0KYS6 PAC:16967259 Cucumis sativus 528  
Cucsa.179980.3 A0A0A0KYS6 PAC:16967260 Cucumis sativus 528  
Cucsa.179980.4 PAC:16967261 Cucumis sativus 525  
Cucsa.179980.1 A0A0A0KYS6 PAC:16967258 Cucumis sativus 528  
Cucsa.179980.7 PAC:16967264 Cucumis sativus 392  
Cucsa.179980.8 PAC:16967265 Cucumis sativus 388  
Cucsa.194040.1 A0A0A0LKC8 PAC:16968130 Cucumis sativus 471  
orange1.1g012104m PAC:18115501 Citrus sinensis 471  
orange1.1g018318m PAC:18115502 Citrus sinensis 358  
orange1.1g032537m A0A067D1B1 PAC:18129199 Citrus sinensis 138  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8305478
            10828359
            11877399