Protein Domain : IPR000387

Type:  Domain Name:  Tyrosine specific protein phosphatases domain
Description:  Tyrosine specific protein phosphatases (PTPases) contain two conserved cysteines, the second one has been shown to be absolutely required for activity. This entry represents the PTPase domain that centre on the active site cysteine. A number of conserved residues in its immediate vicinity have also been shown to be important. Protein tyrosine (pTyr) phosphorylation is a common post-translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. Consequently, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. Tyrosine-specific protein phosphatases (PTPase; ) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. These enzymes are key regulatory components in signal transduction pathways (such as the MAP kinase pathway) and cell cycle control, and are important in the control of cell growth, proliferation, differentiation and transformation [, ]. The PTP superfamily can be divided into four subfamilies []:(1) pTyr-specific phosphatases(2) dual specificity phosphatases (dTyr and dSer/dThr)(3) Cdc25 phosphatases (dTyr and/or dThr)(4) LMW (low molecular weight) phosphatasesBased on their cellular localisation, PTPases are also classified as:Receptor-like, which are transmembrane receptors that contain PTPase domains []Non-receptor (intracellular) PTPases []All PTPases carry the highly conserved active site motif C(X)5R (PTP signature motif), employ a common catalytic mechanism, and share a similar core structure made of a central parallel beta-sheet with flanking alpha-helices containing a beta-loop-alpha-loop that encompasses the PTP signature motif []. Functional diversity between PTPases is endowed by regulatory domains and subunits. Short Name:  TYR_PHOSPHATASE_dom
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2 Child Features

DB identifier Type Name
IPR020422 Domain Dual specificity protein phosphatase domain
IPR000242 Domain PTP type protein phosphatase

1 Contains

DB identifier Type Name
IPR016130 Active_site Protein-tyrosine phosphatase, active site

1 Cross References

Identifier
PS50056

20 Found Ins

DB identifier Type Name
IPR000340 Domain Dual specificity phosphatase, catalytic domain
IPR017074 Family mRNA capping enzyme, bifunctional
IPR020417 Family Atypical dual specificity phosphatase
IPR016278 Family Dual specificity protein phosphatase 12
IPR020420 Family Atypical dual specificity phosphatase, subfamily B
IPR008356 Family Protein-tyrosine phosphatase, KIM-containing
IPR003546 Family Type III secreted modular tyrosine phosphatase, SptP/YopH
IPR012151 Family Protein-tyrosine phosphatase, non-receptor type-3, -4
IPR012152 Family Protein-tyrosine phosphatase, non-receptor type-6, -11
IPR012265 Family Protein-tyrosine phosphatase, non-receptor type-1/2
IPR020405 Family Atypical dual specificity phosphatase, subfamily A
IPR012266 Family Protein-tyrosine phosphatase, non-receptor type-12
IPR014392 Family Protein-tyrosine phosphatase, non-receptor type-14, -21
IPR012153 Family Tyrosine-protein phosphatase non-receptor type 13
IPR016336 Family Receptor tyrosine-protein phosphatase, alpha/epsilon-type
IPR016335 Family Receptor-type tyrosine-protein phosphatase C
IPR016334 Family Protein-tyrosine phosphatase, receptor type R/non-receptor type 5
IPR016276 Family Non-receptor tyrosine-protein phosphatase 22
IPR016277 Family Tyrosine-protein phosphatase 1
IPR008425 Family Cyclin-dependent kinase inhibitor 3

2 GO Annotations

GO Term Gene Name
GO:0016791 IPR000387
GO:0016311 IPR000387

2 Ontology Annotations

GO Term Gene Name
GO:0016791 IPR000387
GO:0016311 IPR000387

1 Parent Features

DB identifier Type Name
IPR029021 Domain Protein-tyrosine phosphatase-like

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
92881 D8RG08 PAC:15421425 Selaginella moellendorffii 725  
410976 D8RHL7 PAC:15409573 Selaginella moellendorffii 268  
231635 D8RHE3 PAC:15418278 Selaginella moellendorffii 164  
36819 D8RL57 PAC:15412257 Selaginella moellendorffii 174  
412678 D8RL46 PAC:15413200 Selaginella moellendorffii 233  
97017 D8RMK4 PAC:15407453 Selaginella moellendorffii 350  
27743 D8RQX2 PAC:15407144 Selaginella moellendorffii 172  
34445 D8RS38 PAC:15403319 Selaginella moellendorffii 255  
100916 D8RTN6 PAC:15403908 Selaginella moellendorffii 560  
6245 D8RTR0 PAC:15420138 Selaginella moellendorffii 114  
416191 D8RYD2 PAC:15420989 Selaginella moellendorffii 201  
418145 D8S4T9 PAC:15404346 Selaginella moellendorffii 288  
68807 D8QYM1 PAC:15417327 Selaginella moellendorffii 84  
418983 D8S7F7 PAC:15410710 Selaginella moellendorffii 174  
113946 D8SCL1 PAC:15420089 Selaginella moellendorffii 167  
406660 D8R123 PAC:15417631 Selaginella moellendorffii 206  
35954 D8SKE1 PAC:15410215 Selaginella moellendorffii 213  
83906 D8R2W0 PAC:15417857 Selaginella moellendorffii 155  
66231 D8R6S8 PAC:15406880 Selaginella moellendorffii 299  
27712 D8QQ09 PAC:15407087 Selaginella moellendorffii 94  
27710 D8T0S8 PAC:15407084 Selaginella moellendorffii 95  
27738 D8SZJ9 PAC:15407127 Selaginella moellendorffii 174  
409515 D8RBP9 PAC:15403088 Selaginella moellendorffii 249  
437707 D8QP09 PAC:15420447 Selaginella moellendorffii 271  
408631 D8R9F9 PAC:15423293 Selaginella moellendorffii 210  
127483 D8SYC1 PAC:15412944 Selaginella moellendorffii 199  
36025 D8RC28 PAC:15406092 Selaginella moellendorffii 162  
91859 D8RE91 PAC:15418580 Selaginella moellendorffii 341  
91575 D8REX4 PAC:15416329 Selaginella moellendorffii 215  
evm.model.supercontig_128.70 PAC:16407498 Carica papaya 357  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9818190
            14625689
            12678841
            16672235
            8948575
            9646865