Protein Domain : IPR020422

Type:  Domain Name:  Dual specificity protein phosphatase domain
Description:  Tyrosine specific protein phosphatases (PTPases) contain two conserved cysteines, the second one has been shown to be absolutely required for activity. This entry represents the PTPase domain that centre on the active site cysteine. A number of conserved residues in its immediate vicinity have also been shown to be important. This domain can be found in dual specificity phosphatases. Dual specificity phosphatases (DUSPs) are members of the superfamily of protein tyrosine phosphatases [, ]. They remove the phosphate group from both phospho-tyrosine and phospho-serine/threonine residues. In general, DUSPs are classified into the following subgroups []:Slingshot phosphatasesPhosphatase of regenerating liver (PRL)Cdc14 phosphatasesPhosphatase and tensin homologue deleted on chromosome 10 (PTEN)-like and myotubularin phosphatasesMitogen-activated protein kinase phosphatases (MKPs)Atypical DUSPs Short Name:  TYR_PHOSPHATASE_DUAL_dom
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0 Child Features

1 Contains

DB identifier Type Name
IPR016130 Active_site Protein-tyrosine phosphatase, active site

2 Cross Referencess

Identifier
PS50054
SM00195

5 Found Ins

DB identifier Type Name
IPR020417 Family Atypical dual specificity phosphatase
IPR016278 Family Dual specificity protein phosphatase 12
IPR020420 Family Atypical dual specificity phosphatase, subfamily B
IPR020405 Family Atypical dual specificity phosphatase, subfamily A
IPR008343 Family Mitogen-activated protein (MAP) kinase phosphatase

2 GO Annotations

GO Term Gene Name
GO:0008138 IPR020422
GO:0006470 IPR020422

2 Ontology Annotations

GO Term Gene Name
GO:0008138 IPR020422
GO:0006470 IPR020422

1 Parent Features

DB identifier Type Name
IPR000387 Domain Tyrosine specific protein phosphatases domain

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
92881 D8RG08 PAC:15421425 Selaginella moellendorffii 725  
36819 D8RL57 PAC:15412257 Selaginella moellendorffii 174  
412678 D8RL46 PAC:15413200 Selaginella moellendorffii 233  
97017 D8RMK4 PAC:15407453 Selaginella moellendorffii 350  
27743 D8RQX2 PAC:15407144 Selaginella moellendorffii 172  
34445 D8RS38 PAC:15403319 Selaginella moellendorffii 255  
100916 D8RTN6 PAC:15403908 Selaginella moellendorffii 560  
6245 D8RTR0 PAC:15420138 Selaginella moellendorffii 114  
416191 D8RYD2 PAC:15420989 Selaginella moellendorffii 201  
68807 D8QYM1 PAC:15417327 Selaginella moellendorffii 84  
418983 D8S7F7 PAC:15410710 Selaginella moellendorffii 174  
113946 D8SCL1 PAC:15420089 Selaginella moellendorffii 167  
406660 D8R123 PAC:15417631 Selaginella moellendorffii 206  
35954 D8SKE1 PAC:15410215 Selaginella moellendorffii 213  
27712 D8QQ09 PAC:15407087 Selaginella moellendorffii 94  
27710 D8T0S8 PAC:15407084 Selaginella moellendorffii 95  
27738 D8SZJ9 PAC:15407127 Selaginella moellendorffii 174  
437707 D8QP09 PAC:15420447 Selaginella moellendorffii 271  
408631 D8R9F9 PAC:15423293 Selaginella moellendorffii 210  
127483 D8SYC1 PAC:15412944 Selaginella moellendorffii 199  
36025 D8RC28 PAC:15406092 Selaginella moellendorffii 162  
91859 D8RE91 PAC:15418580 Selaginella moellendorffii 341  
91575 D8REX4 PAC:15416329 Selaginella moellendorffii 215  
evm.model.supercontig_128.70 PAC:16407498 Carica papaya 357  
evm.model.supercontig_132.48 PAC:16408144 Carica papaya 298  
evm.model.supercontig_16.19 PAC:16410040 Carica papaya 179  
evm.model.supercontig_19.85 PAC:16412099 Carica papaya 292  
evm.model.supercontig_4.108 PAC:16419184 Carica papaya 882  
evm.model.supercontig_56.109 PAC:16422704 Carica papaya 695  
evm.model.supercontig_56.15 PAC:16422720 Carica papaya 193  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            17057753
            15186772
            19228121