Protein Domain : IPR020420

Type:  Family Name:  Atypical dual specificity phosphatase, subfamily B
Description:  Dual specificity phosphatases (DUSPs) are members of the superfamily of protein tyrosine phosphatases [, ]. They remove the phosphate group from both phospho-tyrosine and phospho-serine/threonine residues. In general, DUSPs are classified into the following subgroups []:Slingshot phosphatasesPhosphatase of regenerating liver (PRL)Cdc14 phosphatasesPhosphatase and tensin homologue deleted on chromosome 10 (PTEN)-like and myotubularin phosphatasesMitogen-activated protein kinase phosphatases (MKPs)Atypical DUSPsThe atypical DUSPs share a high degree of similarity with the MKP subgroup, but lack the N-terminal regulatory domain, which provides the substrate specificity towards the MAP kinases. These atypical-DUSPs form a heterogeneous group and have in common the presence of a single catalytic PTP domain. VHR was the first characterised member of this subfamily; its crystal structure is known [, ].The function of many atypical DUSPs remains unknown, although some have been related to regulation of MAP kinase pathways [, , ]. VHR has also been related to the control of cell-senescence []. The atypical DUSPs can be subdivided into two groups (termed A and B) on the basis of sequence similarity. Each of these subgroups is characterised by its own distinctive set of motifs, the functions of which are as yet unknown.This entry also includes DUSP1 which does not belong to the atypical DUSP family. Short Name:  Atypical_DUSP_famB
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0 Child Features

4 Contains

DB identifier Type Name
IPR000340 Domain Dual specificity phosphatase, catalytic domain
IPR020422 Domain Dual specificity protein phosphatase domain
IPR000387 Domain Tyrosine specific protein phosphatases domain
IPR016130 Active_site Protein-tyrosine phosphatase, active site

1 Cross References

Identifier
PR01910

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0017017 IPR020420

1 Ontology Annotations

GO Term Gene Name
GO:0017017 IPR020420

1 Parent Features

DB identifier Type Name
IPR020417 Family Atypical dual specificity phosphatase

13 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Cagra.0026s0074.1.p PAC:28919713 Capsella grandiflora 203  
Manes.15G023800.1.p A0A2C9UCD9 PAC:32352480 Manihot esculenta 174  
AUR62030097-RA PAC:36291727 Chenopodium quinoa 195  
Anaoc.0004s0096.1.p PAC:37492809 Anacardium occidentale 176  
Carub.0003s2384.1.p R0G7M6 PAC:39242938 Capsella rubella 203  
Eusyr.0017s0013.1.p PAC:39704076 Euclidium syriacum 195  
Clevi.0013s0419.1.p PAC:39743351 Cleome violacea 173  
Stapi.3052s0003.1.p PAC:39831093 Stanleya pinnata 197  
Distr.0013s0294.1.p PAC:40030574 Diptychocarpus strictus 195  
Distr.0020s20000.1.p PAC:45566201 Diptychocarpus strictus 195  
Clevi.0010s1342.2.p PAC:45684704 Cleome violacea 173  
Clevi.0010s1342.1.p PAC:45684703 Cleome violacea 233  
Manes.15G023800.1.p PAC:50316033 Manihot esculenta 174  

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8650541
            17057753
            15186772
            1281549
            10224087
            11971192
            15796912
            16604064
            19228121