Protein Domain : IPR016130

Type:  Active_site Name:  Protein-tyrosine phosphatase, active site
Description:  This entry includes proteins of two subfamilies: Ser/Thr () and Tyr dual specificity protein phosphatase and tyrosine specific protein phosphatase (). Both of these subfamilies may also have inactive phosphatase domains, and dependent on the domain composition this loss of catalytic activity has different effects on protein function. Inactive single domain phosphatases can still specifically bind substrates, and protect against dephosphorylation, while the inactive domains of tandem phosphatases can be further subdivided into two classes. Those which bind phosphorylated tyrosine residues may recruit multi-phosphorylated substrates for the adjacent active domains and are more conserved, while the other class have accumulated several variable amino acid substitutions and have a complete loss of tyrosine binding capability. The second class shows a release of evolutionary constraint for the sites around the catalytic centre, which emphasises a difference in function from the first group. There is a region of higher conservation common to both classes, suggesting a regulatory centre [].Ser/Thr and Tyr dual specificity phosphatases are a group of enzymes with both Ser/Thr () and tyrosine specific protein phosphatase () activity able to remove both the serine/threonine or tyrosine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase. Dual specificity protein phosphatases (DSPs) regulate mitogenic signal transduction and control the cell cycle. Tyrosine specific protein phosphatases catalyze the removal of a phosphate group attached to a tyrosine residue. They are also very important in the control of cell growth, proliferation, differentiation and transformation. Short Name:  Tyr_Pase_AS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00383

16 Found Ins

DB identifier Type Name
IPR000340 Domain Dual specificity phosphatase, catalytic domain
IPR020422 Domain Dual specificity protein phosphatase domain
IPR000387 Domain Tyrosine specific protein phosphatases domain
IPR020428 Family Protein-tyrosine phosphatase SIW14-like, eukaryotic
IPR003595 Domain Protein-tyrosine phosphatase, catalytic
IPR000242 Domain PTP type protein phosphatase
IPR020417 Family Atypical dual specificity phosphatase
IPR020420 Family Atypical dual specificity phosphatase, subfamily B
IPR008356 Family Protein-tyrosine phosphatase, KIM-containing
IPR003546 Family Type III secreted modular tyrosine phosphatase, SptP/YopH
IPR012151 Family Protein-tyrosine phosphatase, non-receptor type-3, -4
IPR012152 Family Protein-tyrosine phosphatase, non-receptor type-6, -11
IPR012265 Family Protein-tyrosine phosphatase, non-receptor type-1/2
IPR020405 Family Atypical dual specificity phosphatase, subfamily A
IPR012266 Family Protein-tyrosine phosphatase, non-receptor type-12
IPR014392 Family Protein-tyrosine phosphatase, non-receptor type-14, -21

3 GO Annotations

GO Term Gene Name
GO:0004725 IPR016130
GO:0016791 IPR016130
GO:0016311 IPR016130

3 Ontology Annotations

GO Term Gene Name
GO:0004725 IPR016130
GO:0016791 IPR016130
GO:0016311 IPR016130

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14739250