Protein Domain : IPR000242

Type:  Domain Name:  PTP type protein phosphatase
Description:  This entry represents the PTPase domain found in several tyrosine-specific protein phosphatases (PTPases).Structurally, all known receptor PTPases, are made up of a variable length extracellular domain, followed by a transmembrane region and a C-terminalcatalytic cytoplasmic domain. Some of the receptor PTPases contain fibronectin type III (FN-III) repeats, immunoglobulin-like domains, MAM domains orcarbonic anhydrase-like domains in their extracellular region. The cytoplasmic region generally contains two copies of the PTPase domain. The first seems tohave enzymatic activity, while the second is inactive. The inactive domains of tandem phosphatases can be divided into two classes. Those which bind phosphorylated tyrosine residues may recruit multi-phosphorylated substrates for the adjacent active domains and are more conserved, while the other class have accumulated several variable amino acid substitutions and have a complete loss of tyrosine binding capability. The second class shows a release of evolutionary constraint for the sites around the catalytic centre, which emphasises a difference in function from the first group. There is a region of higher conservation common to both classes, suggesting a new regulatory centre []. PTPase domains consist of about 300 amino acids. There are two conserved cysteines, the second one has been shown to be absolutely required for activity. Furthermore, a number of conserved residues in its immediate vicinity have also been shown to be important.Protein tyrosine (pTyr) phosphorylation is a common post-translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. Consequently, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. Tyrosine-specific protein phosphatases (PTPase; ) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. These enzymes are key regulatory components in signal transduction pathways (such as the MAP kinase pathway) and cell cycle control, and are important in the control of cell growth, proliferation, differentiation and transformation [, ]. The PTP superfamily can be divided into four subfamilies []:(1) pTyr-specific phosphatases(2) dual specificity phosphatases (dTyr and dSer/dThr)(3) Cdc25 phosphatases (dTyr and/or dThr)(4) LMW (low molecular weight) phosphatasesBased on their cellular localisation, PTPases are also classified as:Receptor-like, which are transmembrane receptors that contain PTPase domains []Non-receptor (intracellular) PTPases []All PTPases carry the highly conserved active site motif C(X)5R (PTP signature motif), employ a common catalytic mechanism, and share a similar core structure made of a central parallel beta-sheet with flanking alpha-helices containing a beta-loop-alpha-loop that encompasses the PTP signature motif []. Functional diversity between PTPases is endowed by regulatory domains and subunits. Short Name:  PTPase_domain
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1 Child Features

DB identifier Type Name
IPR003595 Domain Protein-tyrosine phosphatase, catalytic

1 Contains

DB identifier Type Name
IPR016130 Active_site Protein-tyrosine phosphatase, active site

4 Cross Referencess

Identifier
PF00102
PR00700
PS50055
SM00194

11 Found Ins

DB identifier Type Name
IPR003546 Family Type III secreted modular tyrosine phosphatase, SptP/YopH
IPR012151 Family Protein-tyrosine phosphatase, non-receptor type-3, -4
IPR012152 Family Protein-tyrosine phosphatase, non-receptor type-6, -11
IPR012265 Family Protein-tyrosine phosphatase, non-receptor type-1/2
IPR012266 Family Protein-tyrosine phosphatase, non-receptor type-12
IPR014392 Family Protein-tyrosine phosphatase, non-receptor type-14, -21
IPR012153 Family Tyrosine-protein phosphatase non-receptor type 13
IPR016336 Family Receptor tyrosine-protein phosphatase, alpha/epsilon-type
IPR016335 Family Receptor-type tyrosine-protein phosphatase C
IPR016334 Family Protein-tyrosine phosphatase, receptor type R/non-receptor type 5
IPR016276 Family Non-receptor tyrosine-protein phosphatase 22

2 GO Annotations

GO Term Gene Name
GO:0004725 IPR000242
GO:0006470 IPR000242

2 Ontology Annotations

GO Term Gene Name
GO:0004725 IPR000242
GO:0006470 IPR000242

1 Parent Features

DB identifier Type Name
IPR000387 Domain Tyrosine specific protein phosphatases domain

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
410976 D8RHL7 PAC:15409573 Selaginella moellendorffii 268  
418145 D8S4T9 PAC:15404346 Selaginella moellendorffii 288  
83906 D8R2W0 PAC:15417857 Selaginella moellendorffii 155  
66231 D8R6S8 PAC:15406880 Selaginella moellendorffii 299  
409515 D8RBP9 PAC:15403088 Selaginella moellendorffii 249  
evm.model.supercontig_64.134 PAC:16424207 Carica papaya 343  
29859.m000083 B9T701 PAC:16811650 Ricinus communis 332  
Cucsa.003210.1 PAC:16950960 Cucumis sativus 181  
Cucsa.003210.2 PAC:16950961 Cucumis sativus 181  
Cucsa.079890.1 PAC:16956278 Cucumis sativus 353  
orange1.1g029680m A0A067G5D8 PAC:18105764 Citrus sinensis 189  
orange1.1g030712m A0A067G5G0 PAC:18105765 Citrus sinensis 173  
orange1.1g020165m A0A067H8L7 PAC:18092394 Citrus sinensis 330  
orange1.1g019528m A0A067GW41 PAC:18092393 Citrus sinensis 339  
orange1.1g023691m A0A067GZ32 PAC:18092395 Citrus sinensis 278  
orange1.1g019277m A0A067H890 PAC:18092391 Citrus sinensis 343  
orange1.1g019565m A0A067GW41 PAC:18092392 Citrus sinensis 339  
AT1G71860.1 O82656 PAC:19649669 Arabidopsis thaliana 340  
AT1G71860.2 F4IA41 PAC:19649671 Arabidopsis thaliana 277  
AT1G71860.3 O82656 PAC:19649670 Arabidopsis thaliana 340  
Thhalv10018624m V4JS01 PAC:20191633 Eutrema salsugineum 414  
Ciclev10001727m V4SJH1 PAC:20788906 Citrus clementina 343  
Lus10021940 PAC:23158055 Linum usitatissimum 175  
Lus10034033 PAC:23154691 Linum usitatissimum 125  
Lus10028712 PAC:23164585 Linum usitatissimum 336  
Lus10006053 PAC:23147730 Linum usitatissimum 342  
Potri.013G115400.3 PAC:26995649 Populus trichocarpa 264  
Potri.013G115400.1 B9MW58 PAC:26995647 Populus trichocarpa 339  
Potri.013G115400.2 PAC:26995648 Populus trichocarpa 338  
Potri.019G086000.1 A0A2K1WRN7 PAC:27025290 Populus trichocarpa 168  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14739250
            9818190
            14625689
            12678841
            16672235
            8948575
            9646865