Protein Domain : IPR016276

Type:  Family Name:  Non-receptor tyrosine-protein phosphatase 22
Description:  Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) acts as negative regulator of T-cell receptor (TCR) signalling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signalling molecules [].Variations of the PTPN22 gene affects the susceptibility of systemic lupus erythematosus (SLE) []. Short Name:  PTPN22
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0 Child Features

2 Contains

DB identifier Type Name
IPR000387 Domain Tyrosine specific protein phosphatases domain
IPR000242 Domain PTP type protein phosphatase

2 Cross Referencess

Identifier
PTHR19134:SF260
PIRSF000930

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004725 IPR016276
GO:0050856 IPR016276

2 Ontology Annotations

GO Term Gene Name
GO:0004725 IPR016276
GO:0050856 IPR016276

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8890164
            15273934