Protein Domain : IPR014392

Type:  Family Name:  Protein-tyrosine phosphatase, non-receptor type-14, -21
Description:  Protein tyrosine (pTyr) phosphorylation is a common post-translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. Consequently, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. Tyrosine-specific protein phosphatases (PTPase; ) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. These enzymes are key regulatory components in signal transduction pathways (such as the MAP kinase pathway) and cell cycle control, and are important in the control of cell growth, proliferation, differentiation and transformation [, ]. The PTP superfamily can be divided into four subfamilies []:(1) pTyr-specific phosphatases(2) dual specificity phosphatases (dTyr and dSer/dThr)(3) Cdc25 phosphatases (dTyr and/or dThr)(4) LMW (low molecular weight) phosphatasesBased on their cellular localisation, PTPases are also classified as:Receptor-like, which are transmembrane receptors that contain PTPase domains []Non-receptor (intracellular) PTPases []All PTPases carry the highly conserved active site motif C(X)5R (PTP signature motif), employ a common catalytic mechanism, and share a similar core structure made of a central parallel beta-sheet with flanking alpha-helices containing a beta-loop-alpha-loop that encompasses the PTP signature motif []. Functional diversity between PTPases is endowed by regulatory domains and subunits. This entry represents a tyrosine-protein phosphatase, non-receptor types 14 and 21. Short Name:  Tyr_Pase_non-rcpt_typ-14/21
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0 Child Features

10 Contains

DB identifier Type Name
IPR011993 Domain Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
IPR000387 Domain Tyrosine specific protein phosphatases domain
IPR000242 Domain PTP type protein phosphatase
IPR019748 Domain FERM central domain
IPR018979 Domain FERM, N-terminal
IPR000299 Domain FERM domain
IPR019749 Domain Band 4.1 domain
IPR016130 Active_site Protein-tyrosine phosphatase, active site
IPR019747 Conserved_site FERM conserved site
IPR018980 Domain FERM, C-terminal PH-like domain

1 Cross References

Identifier
PIRSF000934

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004725 IPR014392
GO:0006470 IPR014392

2 Ontology Annotations

GO Term Gene Name
GO:0004725 IPR014392
GO:0006470 IPR014392

0 Parent Features

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9818190
            14625689
            12678841
            16672235
            8948575
            9646865