Protein Domain : IPR001412

Type:  Conserved_site Name:  Aminoacyl-tRNA synthetase, class I, conserved site
Description:  The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c.This entry represents a conserved sequence in their N-terminal section of class I aminoacyl-tRNA synthetases. Short Name:  aa-tRNA-synth_I_CS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00178

19 Found Ins

DB identifier Type Name
IPR002307 Family Tyrosine-tRNA ligase
IPR004526 Family Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic
IPR001278 Family Arginine-tRNA ligase
IPR014729 Domain Rossmann-like alpha/beta/alpha sandwich fold
IPR002301 Family Isoleucine-tRNA ligase
IPR002300 Domain Aminoacyl-tRNA synthetase, class Ia
IPR002305 Family Aminoacyl-tRNA synthetase, class Ic
IPR014758 Family Methionyl-tRNA synthetase
IPR015413 Family Methionyl/Leucyl tRNA synthetase
IPR004493 Family Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic
IPR002306 Family Tryptophan-tRNA ligase
IPR020058 Domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
IPR004527 Family Glutamate-tRNA ligase, bacterial/mitochondrial
IPR000924 Family Glutamyl/glutaminyl-tRNA synthetase
IPR004514 Family Glutamine-tRNA synthetase
IPR002303 Family Valine-tRNA ligase
IPR002302 Family Leucine-tRNA ligase
IPR020791 Family Leucine-tRNA ligase, archaeal
IPR002904 Family Lysine-tRNA ligase

4 GO Annotations

GO Term Gene Name
GO:0000166 IPR001412
GO:0004812 IPR001412
GO:0005524 IPR001412
GO:0006418 IPR001412

4 Ontology Annotations

GO Term Gene Name
GO:0000166 IPR001412
GO:0004812 IPR001412
GO:0005524 IPR001412
GO:0006418 IPR001412

0 Parent Features

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8364025
            8274143
            1852601
            2053131
            10673435
            2203971