Protein Domain : IPR000924

Type:  Family Name:  Glutamyl/glutaminyl-tRNA synthetase
Description:  The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c.Glutamate-tRNA ligase (also known as glutamyl-tRNA synthetase)() is a class Ic ligase and shows several similarities with glutamate-tRNA ligase concerning structure and catalytic properties. It is an alpha2 dimer. To date one crystal structure of a glutamate-tRNA ligase (Thermus thermophilus) has been solved. The molecule has the form of a bent cylinder and consists of four domains. The N-terminal half (domains 1 and 2) contains the 'Rossman fold' typical for class I ligases and resembles the corresponding part of Escherichia coliGlnRS, whereas the C-terminal half exhibits a GluRS-specific structure []. Short Name:  Glu/Gln-tRNA-synth
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4 Child Features

DB identifier Type Name
IPR004526 Family Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic
IPR004527 Family Glutamate-tRNA ligase, bacterial/mitochondrial
IPR004514 Family Glutamine-tRNA synthetase
IPR022380 Family Glutamyl-Q tRNA(Asp) synthetase

10 Contains

DB identifier Type Name
IPR014729 Domain Rossmann-like alpha/beta/alpha sandwich fold
IPR020751 Domain Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2
IPR011035 Domain Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain
IPR020058 Domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
IPR008925 Domain Aminoacyl-tRNA synthetase, class I, anticodon-binding
IPR020059 Domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain
IPR020056 Domain Ribosomal protein L25/Gln-tRNA synthetase, beta-barrel domain
IPR020752 Domain Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 1
IPR020061 Domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, alpha-bundle domain
IPR001412 Conserved_site Aminoacyl-tRNA synthetase, class I, conserved site

2 Cross Referencess

Identifier
PTHR10119
PR00987

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0000166 IPR000924
GO:0005524 IPR000924
GO:0016876 IPR000924
GO:0043039 IPR000924
GO:0005737 IPR000924

5 Ontology Annotations

GO Term Gene Name
GO:0000166 IPR000924
GO:0005524 IPR000924
GO:0016876 IPR000924
GO:0043039 IPR000924
GO:0005737 IPR000924

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
172681 D8RME9 PAC:15413541 Selaginella moellendorffii 555  
404079 D8QU78 PAC:15407088 Selaginella moellendorffii 760  
78641 D8QV01 PAC:15422958 Selaginella moellendorffii 763  
121308 D8SNX9 PAC:15416746 Selaginella moellendorffii 731  
168502 D8R589 PAC:15422789 Selaginella moellendorffii 767  
evm.TU.contig_29182.1 PAC:16429677 Carica papaya 583  
evm.model.supercontig_248.3 PAC:16414659 Carica papaya 729  
evm.model.supercontig_798.2 PAC:16426373 Carica papaya 795  
30066.m000715 B9SLX3 PAC:16816481 Ricinus communis 793  
30128.m008996 B9RFS6 PAC:16818580 Ricinus communis 728  
28592.m000288 B9T2L7 PAC:16801181 Ricinus communis 577  
Cucsa.051070.1 A0A0A0LYW4 PAC:16954173 Cucumis sativus 729  
Cucsa.099920.8 PAC:16958495 Cucumis sativus 452  
Cucsa.099920.2 A0A0A0K502 PAC:16958489 Cucumis sativus 573  
Cucsa.099920.1 PAC:16958488 Cucumis sativus 596  
Cucsa.109570.1 A0A0A0LIR0 PAC:16959890 Cucumis sativus 794  
Cucsa.234080.1 A0A0A0LMF7 PAC:16970337 Cucumis sativus 793  
orange1.1g006869m A0A067GNF2 PAC:18139053 Citrus sinensis 628  
orange1.1g007060m A0A067GBC2 PAC:18139054 Citrus sinensis 619  
orange1.1g004119m A0A067GE73 PAC:18139051 Citrus sinensis 773  
orange1.1g004546m A0A067GNR0 PAC:18139052 Citrus sinensis 745  
orange1.1g003764m A0A067GBI4 PAC:18139050 Citrus sinensis 797  
orange1.1g003751m A0A067GBB7 PAC:18139049 Citrus sinensis 798  
orange1.1g013441m A0A067FQE2 PAC:18099486 Citrus sinensis 443  
orange1.1g008289m A0A067FLS8 PAC:18099485 Citrus sinensis 571  
orange1.1g043341m A0A067DV09 PAC:18107196 Citrus sinensis 758  
AT5G26710.1 O82462 PAC:19670447 Arabidopsis thaliana 719  
AT5G64050.1 Q9FEA2 PAC:19670485 Arabidopsis thaliana 570  
AT1G25350.1 Q8W4F3 PAC:19655199 Arabidopsis thaliana 795  
Thhalv10006840m V4KSE7 PAC:20187784 Eutrema salsugineum 795  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8364025
            8274143
            1852601
            2053131
            9426192
            10673435
            2203971