Protein Domain : IPR004514

Type:  Family Name:  Glutamine-tRNA synthetase
Description:  Glutamine-tRNA ligase () is a class Ic aminoacyl-tRNA ligase and shows several similarities with glutamine-tRNA ligase concerning structure and catalytic properties. It is an alpha2 dimer.Glutamine-tRNA ligase is a relatively rare ligase, found in the cytosolic compartment of eukaryotes, in Escherichia coliand a number of other Gram-negative bacteria, and in Deinococcus radiodurans. In contrast, the pathway to Gln-tRNA in mitochondria, Archaea, Gram-positive bacteria, and a number of other lineages is by misacylation with Glu followed by transamidation to correct the aminoacylation to Gln.The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c. Short Name:  Gln-tRNA-synth
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1 Child Features

DB identifier Type Name
IPR022861 Family Glutamine-tRNA ligase, bacterial

6 Contains

DB identifier Type Name
IPR011035 Domain Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain
IPR020058 Domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
IPR020059 Domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain
IPR020056 Domain Ribosomal protein L25/Gln-tRNA synthetase, beta-barrel domain
IPR020061 Domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, alpha-bundle domain
IPR001412 Conserved_site Aminoacyl-tRNA synthetase, class I, conserved site

1 Cross References

Identifier
TIGR00440

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0000166 IPR004514
GO:0004819 IPR004514
GO:0005524 IPR004514
GO:0006425 IPR004514
GO:0005737 IPR004514

5 Ontology Annotations

GO Term Gene Name
GO:0000166 IPR004514
GO:0004819 IPR004514
GO:0005524 IPR004514
GO:0006425 IPR004514
GO:0005737 IPR004514

1 Parent Features

DB identifier Type Name
IPR000924 Family Glutamyl/glutaminyl-tRNA synthetase

484 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
404079 D8QU78 PAC:15407088 Selaginella moellendorffii 760  
78641 D8QV01 PAC:15422958 Selaginella moellendorffii 763  
168502 D8R589 PAC:15422789 Selaginella moellendorffii 767  
evm.model.supercontig_798.2 PAC:16426373 Carica papaya 795  
30066.m000715 B9SLX3 PAC:16816481 Ricinus communis 793  
Cucsa.109570.1 A0A0A0LIR0 PAC:16959890 Cucumis sativus 794  
Cucsa.234080.1 A0A0A0LMF7 PAC:16970337 Cucumis sativus 793  
orange1.1g006869m A0A067GNF2 PAC:18139053 Citrus sinensis 628  
orange1.1g007060m A0A067GBC2 PAC:18139054 Citrus sinensis 619  
orange1.1g012516m A0A067GBI9 PAC:18139055 Citrus sinensis 462  
orange1.1g004119m A0A067GE73 PAC:18139051 Citrus sinensis 773  
orange1.1g004546m A0A067GNR0 PAC:18139052 Citrus sinensis 745  
orange1.1g003764m A0A067GBI4 PAC:18139050 Citrus sinensis 797  
orange1.1g003751m A0A067GBB7 PAC:18139049 Citrus sinensis 798  
AT1G25350.2 F4ICG2 PAC:19655198 Arabidopsis thaliana 800  
AT1G25350.1 Q8W4F3 PAC:19655199 Arabidopsis thaliana 795  
Thhalv10006840m V4KSE7 PAC:20187784 Eutrema salsugineum 795  
Ciclev10014320m V4UHD9 PAC:20818595 Citrus clementina 797  
Ciclev10014321m V4U700 PAC:20818596 Citrus clementina 796  
Lus10041433 PAC:23146663 Linum usitatissimum 793  
Lus10034339 PAC:23176092 Linum usitatissimum 1091  
Potri.010G122900.1 PAC:26979651 Populus trichocarpa 751  
Potri.008G122200.1 A0A2K1ZFZ9 PAC:27036140 Populus trichocarpa 792  
Potri.008G122200.4 PAC:27036143 Populus trichocarpa 786  
Potri.008G122200.6 PAC:27036145 Populus trichocarpa 504  
Potri.008G122200.2 PAC:27036141 Populus trichocarpa 792  
Potri.008G122200.3 A0A2K1ZG00 PAC:27036142 Populus trichocarpa 791  
Potri.008G122200.5 PAC:27036144 Populus trichocarpa 726  
Gorai.009G347600.2 A0A0D2QT74 PAC:26762636 Gossypium raimondii 779  
Gorai.009G347600.3 A0A0D2SDJ1 PAC:26762637 Gossypium raimondii 706  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8364025
            8274143
            1852601
            2053131
            10673435
            2203971