Protein Domain : IPR002302

Type:  Family Name:  Leucine-tRNA ligase
Description:  Leucine-tRNA ligase () is an alpha monomer that belongs to class Ia. The crystal structure of leucine-tRNA ligase from the hyperthermophile Thermus thermophilushas an overall architecture that is similar to that of isoleucine-tRNA ligase, except that the putative editing domain is inserted at a different position in the primary structure. This feature is unique to prokaryote-like leucine-tRNA ligases, as is the presence of a novel additional flexibly inserted domain []. The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c. Short Name:  Leu-tRNA-ligase
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0 Child Features

4 Contains

DB identifier Type Name
IPR014729 Domain Rossmann-like alpha/beta/alpha sandwich fold
IPR013155 Domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
IPR009008 Domain Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
IPR001412 Conserved_site Aminoacyl-tRNA synthetase, class I, conserved site

4 Cross Referencess

Identifier
PTHR11946:SF7
PR00985
TIGR00396
MF_00049_B

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0000166 IPR002302
GO:0004823 IPR002302
GO:0005524 IPR002302
GO:0006429 IPR002302

4 Ontology Annotations

GO Term Gene Name
GO:0000166 IPR002302
GO:0004823 IPR002302
GO:0005524 IPR002302
GO:0006429 IPR002302

1 Parent Features

DB identifier Type Name
IPR015413 Family Methionyl/Leucyl tRNA synthetase

535 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_152.47 PAC:16409632 Carica papaya 975  
31633.m000035 B9TI41 PAC:16825134 Ricinus communis 130  
Cucsa.044980.2 PAC:16953292 Cucumis sativus 976  
Cucsa.044980.3 PAC:16953293 Cucumis sativus 958  
orange1.1g003404m A0A067GI41 PAC:18112545 Citrus sinensis 823  
orange1.1g002217m A0A067GFD3 PAC:18112543 Citrus sinensis 952  
orange1.1g002411m A0A067GF37 PAC:18112544 Citrus sinensis 926  
orange1.1g008100m A0A067GSM1 PAC:18112546 Citrus sinensis 577  
AT4G04350.1 Q9XEA0 PAC:19645380 Arabidopsis thaliana 973  
Thhalv10028396m V4L3D3 PAC:20197707 Eutrema salsugineum 973  
Ciclev10014171m V4UAH7 PAC:20816259 Citrus clementina 951  
Lus10020034 PAC:23156214 Linum usitatissimum 173  
Potri.T037400.1 A0A2K1R8Z0 PAC:26989072 Populus trichocarpa 823  
Potri.011G009600.2 A0A2K1YE48 PAC:27002878 Populus trichocarpa 973  
Potri.011G009600.1 PAC:27002877 Populus trichocarpa 974  
Gorai.010G183100.3 A0A0D2R9T4 PAC:26758316 Gossypium raimondii 976  
Gorai.010G183100.2 A0A0D2R9T4 PAC:26758315 Gossypium raimondii 976  
35259 I0Z871 PAC:27393558 Coccomyxa subellipsoidea C-169 891  
58989 C1MUZ2 PAC:27348084 Micromonas pusilla CCMP1545 1061  
89596 C1FDX5 PAC:27399139 Micromonas sp RCC299 766  
41128 A4RYC7 PAC:27418201 Ostreococcus lucimarinus 879  
Thecc1EG030285t1 A0A061GHZ0 PAC:27439463 Theobroma cacao 980  
Thecc1EG030285t2 A0A061GH97 PAC:27439464 Theobroma cacao 687  
Araha.11756s0144.1.p PAC:28856661 Arabidopsis halleri 836  
Araha.27686s0001.1.p PAC:28857201 Arabidopsis halleri 851  
Cagra.4137s0026.1.p PAC:28904574 Capsella grandiflora 976  
Glyma.07G263100.2.p I1KNG7 PAC:30493132 Glycine max 829  
Glyma.07G263100.3.p A0A0R0J8P7 PAC:30493131 Glycine max 852  
Glyma.07G263100.1.p I1KNG6 PAC:30493130 Glycine max 972  
Brara.C02722.1.p A0A398A1Y1 PAC:30619034 Brassica rapa FPsc 956  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8364025
            8274143
            1852601
            2053131
            10673435
            2203971
            10811626