Protein Domain : IPR005930

Type:  Family Name:  Pyruvate carboxylase
Description:  In the postabsorptive state, blood glucose concentration is kept constant by a combination of glycogenolysis and gluconeogenesis. During prolonged fasting, when hepatic glycogen is exhausted, gluconeogenesis becomes the only source of plasma glucose. Gluconeogenesis (the production of new glucose molecules) occurs mainly in liver and, to a small extent, in kidneys.Pyruvate carboxylase (), a member of the biotin-dependent enzyme family, catalyses the ATP-dependent carboxylation of pyruvate to oxaloacetate, thus playing a crucial role in gluconeogenesis. ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate Most well characterised forms of active enzyme consist of four identical subunits arranged in a tetrahedron-like structure. Each subunit contains three functional domains: the biotin carboxylation domain, the transcarboxylation domain and the biotin carboxyl carrier domain. Short Name:  Pyruv_COase
Paste the following link

0 Child Features

11 Contains

DB identifier Type Name
IPR013785 Domain Aldolase-type TIM barrel
IPR000089 Domain Biotin/lipoyl attachment
IPR011053 Domain Single hybrid motif
IPR011764 Domain Biotin carboxylation domain
IPR005482 Domain Biotin carboxylase, C-terminal
IPR005481 Domain Biotin carboxylase-like, N-terminal domain
IPR011054 Domain Rudiment single hybrid motif
IPR013816 Domain ATP-grasp fold, subdomain 2
IPR000891 Domain Pyruvate carboxyltransferase
IPR003379 Domain Carboxylase, conserved domain
IPR001882 Binding_site Biotin-binding site

2 Cross Referencess

Identifier
PIRSF001594
TIGR01235

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0004736 IPR005930
GO:0005524 IPR005930
GO:0009374 IPR005930
GO:0006090 IPR005930
GO:0006094 IPR005930

5 Ontology Annotations

GO Term Gene Name
GO:0004736 IPR005930
GO:0005524 IPR005930
GO:0009374 IPR005930
GO:0006090 IPR005930
GO:0006094 IPR005930

0 Parent Features

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
26440 I0YIE3 PAC:27388196 Coccomyxa subellipsoidea C-169 1280  
70187 C1MSW8 PAC:27341623 Micromonas pusilla CCMP1545 1254  
96455 C1E910 PAC:27401899 Micromonas sp RCC299 1251  
32964 A4S140 PAC:27419459 Ostreococcus lucimarinus 1132  
Cz04g02090.t1 PAC:38235926 Chromochloris zofingiensis 1297  
Vocar.0002s0643.1.p PAC:32891277 Volvox carteri 1263  

0 Publications