Protein Domain : IPR000089

Type:  Domain Name:  Biotin/lipoyl attachment
Description:  The biotin / lipoyl attachment domain has a conserved lysine residue that binds biotin or lipoic acid. Biotin plays a catalytic role in some carboxyl transfer reactions and is covalently attached, via an amide bond, to a lysine residue in enzymes requiring this coenzyme []. E2 acyltransferases have an essential cofactor, lipoic acid, which is covalently bound via an amide linkage to a lysine group []. The lipoic acid cofactor is found in a variety of proteins that include, H-protein of the glycine cleavage system (GCS), mammalian and yeast pyruvate dehydrogenases and fast migrating protein (FMP) (gene acoC) from Ralstonia eutropha(Alcaligenes eutrophus). Short Name:  Biotin_lipoyl
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0 Child Features

3 Contains

DB identifier Type Name
IPR011053 Domain Single hybrid motif
IPR003016 Binding_site 2-oxo acid dehydrogenase, lipoyl-binding site
IPR001882 Binding_site Biotin-binding site

2 Cross Referencess

Identifier
PF00364
PS50968

8 Found Ins

DB identifier Type Name
IPR006255 Family Dihydrolipoamide succinyltransferase
IPR006257 Family Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
IPR014084 Family Urea carboxylase
IPR005930 Family Pyruvate carboxylase
IPR006256 Family Dihydrolipoamide acetyltransferase pyruvate dehydrogenase complex
IPR015761 Family Lipoamide Acyltransferase
IPR014276 Family 2-oxoglutarate dehydrogenase, E2 component
IPR017695 Domain Selenium-dependent molybdenum hydroxylase system protein, YqeB family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
94277 D8RIN1 PAC:15422739 Selaginella moellendorffii 446  
99356 D8RQU8 PAC:15415855 Selaginella moellendorffii 590  
438632 D8QX63 PAC:15422616 Selaginella moellendorffii 245  
80734 D8QX53 PAC:15407515 Selaginella moellendorffii 71  
82229 D8R0R1 PAC:15409633 Selaginella moellendorffii 431  
407379 D8R5E8 PAC:15418275 Selaginella moellendorffii 1531  
163943 D8QQW2 PAC:15411464 Selaginella moellendorffii 362  
227145 D8QPY3 PAC:15402432 Selaginella moellendorffii 501  
183371 D8SWL6 PAC:15421200 Selaginella moellendorffii 2192  
77392 D8QRV7 PAC:15417976 Selaginella moellendorffii 747  
77384 D8QRE2 PAC:15417942 Selaginella moellendorffii 309  
evm.model.supercontig_1.184 PAC:16404104 Carica papaya 174  
evm.model.supercontig_106.32 PAC:16405196 Carica papaya 545  
evm.model.supercontig_1199.1 PAC:16406631 Carica papaya 374  
evm.model.supercontig_123.26 PAC:16407124 Carica papaya 258  
evm.model.supercontig_128.57 PAC:16407483 Carica papaya 609  
evm.model.supercontig_14.162 PAC:16408661 Carica papaya 326  
evm.model.supercontig_19.114 PAC:16411844 Carica papaya 178  
evm.model.supercontig_336.10 PAC:16417794 Carica papaya 289  
evm.model.supercontig_41.72 PAC:16419605 Carica papaya 180  
evm.model.supercontig_50.171 PAC:16421634 Carica papaya 501  
evm.model.supercontig_66.53 PAC:16424618 Carica papaya 474  
evm.model.supercontig_66.90 PAC:16424659 Carica papaya 1924  
29703.m001477 B9SFG9 PAC:16806173 Ricinus communis 742  
29706.m001326 B9S5V2 PAC:16806339 Ricinus communis 543  
29726.m004073 B9RT82 PAC:16806784 Ricinus communis 504  
29728.m000838 B9SLH2 PAC:16806908 Ricinus communis 473  
29729.m002301 B9S484 PAC:16806950 Ricinus communis 258  
29841.m002812 B9RV21 PAC:16810525 Ricinus communis 225  
29908.m005991 B9RJG2 PAC:16812814 Ricinus communis 2259  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1825611
            1526981