Protein Domain : IPR011053

Type:  Domain Name:  Single hybrid motif
Description:  The single hybrid motif has a beta-barrel sandwich hybrid fold, consisting of a sandwich of half-barrel shaped beta-sheets. This motif is found in biotinyl/lipoyl-carrier proteins and domains, where the biotin and lipoic acid moieties act as covalently attached coenzyme cofactors in enzymes that catalyse metabolic reactions. For example, this motif can be found in the biotinyl domain of Escherichia coliacetyl-CoA carboxylase [], protein H of the glycine cleavage system in Pisum sativum(Garden pea) [], the ipoyl domain of dihydrolipoamide acetyltransferase, which is a component of the pyruvate dehydrogenase complex [], the lipoyl domain of the 2-oxoglutarate dehydrogenase complex [], and the lipoyl domain f the mitochondrial branched-chain alpha-ketoacid dehydrogenase. Short Name:  Single_hybrid_motif
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0 Child Features

2 Contains

DB identifier Type Name
IPR003016 Binding_site 2-oxo acid dehydrogenase, lipoyl-binding site
IPR001882 Binding_site Biotin-binding site

1 Cross References

Identifier
SSF51230

13 Found Ins

DB identifier Type Name
IPR017453 Family Glycine cleavage system H-protein, subgroup
IPR000089 Domain Biotin/lipoyl attachment
IPR006255 Family Dihydrolipoamide succinyltransferase
IPR002930 Family Glycine cleavage system H-protein
IPR006257 Family Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
IPR001249 Family Acetyl-CoA biotin carboxyl carrier
IPR014084 Family Urea carboxylase
IPR005930 Family Pyruvate carboxylase
IPR005776 Family Oxaloacetate decarboxylase, alpha subunit
IPR006256 Family Dihydrolipoamide acetyltransferase pyruvate dehydrogenase complex
IPR015761 Family Lipoamide Acyltransferase
IPR014276 Family 2-oxoglutarate dehydrogenase, E2 component
IPR017514 Family Glycine cleavage system protein H-related, Chlamydia

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
94277 D8RIN1 PAC:15422739 Selaginella moellendorffii 446  
99356 D8RQU8 PAC:15415855 Selaginella moellendorffii 590  
438632 D8QX63 PAC:15422616 Selaginella moellendorffii 245  
80734 D8QX53 PAC:15407515 Selaginella moellendorffii 71  
82229 D8R0R1 PAC:15409633 Selaginella moellendorffii 431  
113331 D8SC67 PAC:15415537 Selaginella moellendorffii 164  
407379 D8R5E8 PAC:15418275 Selaginella moellendorffii 1531  
163943 D8QQW2 PAC:15411464 Selaginella moellendorffii 362  
227145 D8QPY3 PAC:15402432 Selaginella moellendorffii 501  
183371 D8SWL6 PAC:15421200 Selaginella moellendorffii 2192  
74174 D8QPG4 PAC:15407517 Selaginella moellendorffii 185  
77392 D8QRV7 PAC:15417976 Selaginella moellendorffii 747  
77384 D8QRE2 PAC:15417942 Selaginella moellendorffii 309  
evm.model.supercontig_1.184 PAC:16404104 Carica papaya 174  
evm.model.supercontig_106.32 PAC:16405196 Carica papaya 545  
evm.model.supercontig_1199.1 PAC:16406631 Carica papaya 374  
evm.model.supercontig_123.26 PAC:16407124 Carica papaya 258  
evm.model.supercontig_128.57 PAC:16407483 Carica papaya 609  
evm.model.supercontig_135.6 PAC:16408289 Carica papaya 155  
evm.model.supercontig_14.162 PAC:16408661 Carica papaya 326  
evm.model.supercontig_19.114 PAC:16411844 Carica papaya 178  
evm.model.supercontig_26.282 PAC:16415230 Carica papaya 201  
evm.model.supercontig_3.118 PAC:16416389 Carica papaya 393  
evm.model.supercontig_336.10 PAC:16417794 Carica papaya 289  
evm.model.supercontig_41.72 PAC:16419605 Carica papaya 180  
evm.model.supercontig_50.171 PAC:16421634 Carica papaya 501  
evm.model.supercontig_66.53 PAC:16424618 Carica papaya 474  
evm.model.supercontig_66.90 PAC:16424659 Carica papaya 1924  
evm.model.supercontig_90.60 PAC:16428426 Carica papaya 167  
29703.m001477 B9SFG9 PAC:16806173 Ricinus communis 742  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8747466
            10806386
            10913250
            8950276