| Type: | Domain | Name: | Pyruvate carboxyltransferase |
| Description: | Pyruvate carboxylase () (PC), a member of the biotin-dependent enzyme family, is involved in the gluconeogenesis by mediating thecarboxylation of pyruvate to oxaloacetate. Biotin-dependent carboxylase enzymes perform a two step reaction. Enzyme-bound biotin is first carboxylatedby bicarbonate and ATP and the carboxyl group temporarily bound to biotin is subsequently transferred to an acceptor substrate such as pyruvate []. PC hasthree functional domains: a biotin carboxylase (BC) domain, a carboxyltransferase (CT) domain which perform the second part of thereaction and a biotinyl domain [, ]. The mechanism by whichthe carboxyl group is transferred from the carboxybiotin to the pyruvate is not well understood.The pyruvate carboxyltransferase domain is also found in other pyruvate binding enzymes and acetyl-CoA dependent enzymes suggesting that this domaincan be associated with different enzymatic activities.This domain is found towards the N-terminal region of various aldolase enzymes. This N-terminal TIM barrel domain [] interacts with the C-terminal domain. The C-terminal DmpG_comm domain () is thought to promote heterodimerisation with members of to form a bifunctional aldolase-dehydrogenase []. | Short Name: | PYR_CT |
| DB identifier | Type | Name |
|---|---|---|
| IPR011830 | Domain | Isopropylmalate/citramalate/homocitrate synthase |
| DB identifier | Type | Name |
|---|---|---|
| IPR005671 | Family | 2-isopropylmalate synthase, bacterial-type |
| IPR005675 | Family | Citramalate synthase |
| IPR017629 | Family | 4-hydroxy-2-oxovalerate aldolase |
| IPR005930 | Family | Pyruvate carboxylase |
| IPR005668 | Family | 2-isopropylmalate synthase |
| IPR005776 | Family | Oxaloacetate decarboxylase, alpha subunit |
