| Type: | Active_site | Name: | Hydroxymethylglutaryl-CoA lyase, active site |
| Description: | Synonym(s): 3-hydroxy-3-methylglutaryl-coenzyme A synthase, HMG-CoA lyase.HMG-CoA lyase catalyses the transformation of HMG-CoA into acetyl-CoA and acetoacetate. In vertebrates it is a mitochondrial enzyme that is involved in ketogenesis and in leucine catabolism []. In some bacteria, such as Pseudomonas mevalonii, it is involved in mevalonate catabolism (gene mvaB). This signature contains the cysteine that has been shown [], in mvaB, to be required for the activity of the enzyme. | Short Name: | HMG_CoA_lyase_AS |
