GO Term : GO:0004419 hydroxymethylglutaryl-CoA lyase activity GO
Namespace:  molecular_function Obsolete:  false
description  Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.
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0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

3 Ontology Annotations

GO Term Gene Name
GO:0004419 IPR000138
GO:0004419 IPR030020
GO:0004419 IPR030021

8 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0016829 lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
GO:0016833 oxo-acid-lyase activity Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid.
GO:0016830 carbon-carbon lyase activity Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0004419 hydroxymethylglutaryl-CoA lyase activity Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.

7 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
is_a GO:0016833 GO:0004419
is_a GO:0003824 GO:0004419
is_a GO:0016829 GO:0004419
part of GO:0008150 GO:0004419
part of GO:0008152 GO:0004419
is_a GO:0016830 GO:0004419
is_a GO:0003674 GO:0004419

9 Synonyms

Name Type
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming) synonym
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity synonym
3-hydroxy-3-methylglutarate-CoA lyase activity synonym
3-hydroxy-3-methylglutaryl CoA cleaving enzyme synonym
3-hydroxy-3-methylglutaryl coenzyme A lyase activity synonym
3-hydroxy-3-methylglutaryl-CoA lyase activity synonym
HMG-CoA lyase activity synonym
hydroxymethylglutaryl coenzyme A lyase activity synonym
hydroxymethylglutaryl coenzyme A-cleaving enzyme synonym