| Type: | Conserved_site | Name: | Alpha-isopropylmalate/homocitrate synthase, conserved site |
| Description: | A number of enzymes have been shown to be functionally as well as evolutionary related []. The nifV and leuA genes encode homocitrate synthase and alpha-isopropylmalate synthase, respectivelyThe N-terminal parts of NifV and LeuA from bacteria are highly similar to each other []. Homocitrate synthase () (gene nifV) is involved in the biosynthesis of the iron-molybdenum cofactor of nitrogenase and catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate into homocitrate. Alpha-isopropylmalate synthase () catalyses the first step in the biosynthesis of leucine, the condensation ofacetyl-CoA and alpha- ketoisovalerate to form 2-isopropylmalate synthase. | Short Name: | AIPM/Hcit_synth_CS |
| DB identifier | Type | Name |
|---|---|---|
| IPR005671 | Family | 2-isopropylmalate synthase, bacterial-type |
| IPR013785 | Domain | Aldolase-type TIM barrel |
| IPR005675 | Family | Citramalate synthase |
| IPR000891 | Domain | Pyruvate carboxyltransferase |
| IPR005668 | Family | 2-isopropylmalate synthase |
| IPR011872 | Family | Homocitrate synthase, fungi/archaea |
| IPR013477 | Family | Homocitrate synthase NifV-type |
| IPR011830 | Domain | Isopropylmalate/citramalate/homocitrate synthase |
