Protein Domain : IPR013816

Type:  Domain Name:  ATP-grasp fold, subdomain 2
Description:  The ATP-grasp fold is one of several distinct ATP-binding folds, and is found in enzymes that catalyze the formation of amide bonds, catalyzing the ATP-dependent ligation of a carboxylate-containing molecule to an amino or thiol group-containing molecule []. This fold is found in many different enzyme families, including various peptide synthetases, biotin carboxylase, synapsin, succinyl-CoA synthetase, pyruvate phosphate dikinase, and glutathione synthetase, amongst others []. These enzymes contribute predominantly to macromolecular synthesis, using ATP-hydrolysis to activate their substrates. The ATP-grasp fold shares functional and structural similarities with the PIPK (phosphatidylinositol phosphate kinase) and protein kinase superfamilies. The ATP-grasp domain consists of two subdomains with different alpha+beta folds, which grasp the ATP molecule between them. Each subdomain provides a variable loop that forms part of the active site, with regions from other domains also contributing to the active site, even though these other domains are not conserved between the various ATP-grasp enzymes []. This entry represents subdomain 2 found at the C-terminal end of the ATP-grasp domain (the N-terminal subdomain is represented by (). Short Name:  ATP_grasp_subdomain_2
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1 Child Features

DB identifier Type Name
IPR020898 Domain Synapsin, ATP-binding domain

6 Contains

DB identifier Type Name
IPR005482 Domain Biotin carboxylase, C-terminal
IPR011054 Domain Rudiment single hybrid motif
IPR018236 Conserved_site SAICAR synthetase, conserved site
IPR020559 Conserved_site Phosphoribosylglycinamide synthetase, conserved site
IPR000291 Conserved_site D-alanine--D-alanine ligase/VANA/B/C, conserved site
IPR019735 Conserved_site Synapsin, conserved site

1 Cross References

Identifier
G3DSA:3.30.470.20

26 Found Ins

DB identifier Type Name
IPR005809 Family Succinyl-CoA synthetase, beta subunit
IPR005905 Family D-alanine--D-alanine ligase
IPR011095 Domain D-alanine--D-alanine ligase, C-terminal
IPR010121 Family Pyruvate, phosphate dikinase
IPR013650 Domain ATP-grasp fold, succinyl-CoA synthetase-type
IPR011764 Domain Biotin carboxylation domain
IPR006275 Family Carbamoyl-phosphate synthase, large subunit
IPR005483 Domain Carbamoyl-phosphate synthase large subunit, CPSase domain
IPR004549 Family Acetyl-CoA carboxylase, biotin carboxylase
IPR005875 Domain Phosphoribosylaminoimidazole carboxylase, ATPase subunit
IPR016301 Family Phosphoribosylaminoimidazole carboxylase
IPR000115 Family Phosphoribosylglycinamide synthetase
IPR003806 Domain ATP-grasp fold, DUF201-type
IPR013651 Domain ATP-grasp fold, RimK-type
IPR003135 Domain ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type
IPR014084 Family Urea carboxylase
IPR005930 Family Pyruvate carboxylase
IPR020561 Domain Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
IPR006284 Family Glutathione synthetase, prokaryotic
IPR001636 Family Phosphoribosylaminoimidazole-succinocarboxamide synthase
IPR004218 Domain Prokaryotic glutathione synthetase, ATP-binding
IPR005862 Family Phosphoribosylglycinamide formyltransferase 2
IPR014608 Family ATP-citrate synthase
IPR011870 Family Lysine biosynthesis enzyme LysX
IPR001359 Family Synapsin
IPR014106 Family Phosphoribosylaminoimidazole-succinocarboxamide synthase, Vibrio-type

1 GO Annotation

GO Term Gene Name
GO:0005524 IPR013816

1 Ontology Annotations

GO Term Gene Name
GO:0005524 IPR013816

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
136737 D8TCE3 PAC:15419359 Selaginella moellendorffii 174  
411783 D8RJ11 PAC:15411077 Selaginella moellendorffii 557  
411767 D8RIZ5 PAC:15411017 Selaginella moellendorffii 541  
411779 D8RJ07 PAC:15411040 Selaginella moellendorffii 636  
232261 D8RSZ8 PAC:15418206 Selaginella moellendorffii 316  
438375 D8QXH7 PAC:15420474 Selaginella moellendorffii 499  
118674 D8SJV9 PAC:15410193 Selaginella moellendorffii 124  
180525 D8SKF8 PAC:15414053 Selaginella moellendorffii 857  
266998 D8R5U4 PAC:15412292 Selaginella moellendorffii 1309  
126219 D8SW05 PAC:15408218 Selaginella moellendorffii 335  
409077 D8R9C8 PAC:15421710 Selaginella moellendorffii 365  
91571 D8REA7 PAC:15416326 Selaginella moellendorffii 441  
evm.model.supercontig_115.27 PAC:16406190 Carica papaya 506  
evm.model.supercontig_12.209 PAC:16406758 Carica papaya 514  
evm.model.supercontig_160.11 PAC:16410141 Carica papaya 357  
evm.model.supercontig_162.3 PAC:16410252 Carica papaya 525  
evm.model.supercontig_165.35 PAC:16410376 Carica papaya 238  
evm.model.supercontig_198.38 PAC:16412402 Carica papaya 232  
evm.model.supercontig_2592.1 PAC:16415024 Carica papaya 361  
evm.model.supercontig_292.3 PAC:16416325 Carica papaya 404  
evm.model.supercontig_502.2 PAC:16421732 Carica papaya 718  
evm.model.supercontig_69.90 PAC:16424965 Carica papaya 1473  
29908.m006112 B9RJT0 PAC:16812932 Ricinus communis 324  
30065.m001144 B9RXZ3 PAC:16816445 Ricinus communis 1174  
30170.m013637 B9R6S4 PAC:16821486 Ricinus communis 355  
30185.m000954 B9S1E2 PAC:16823058 Ricinus communis 541  
51536.m000018 B9TPY8 PAC:16828413 Ricinus communis 64  
54260.m000027 B9TJB8 PAC:16828702 Ricinus communis 263  
29596.m000711 B9SMZ2 PAC:16803407 Ricinus communis 1228  
28092.m000080 B9T6C3 PAC:16799902 Ricinus communis 1000  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7862655
            9416615
            12392708