Protein Domain : IPR014608

Type:  Family Name:  ATP-citrate synthase
Description:  This entry represents eukaryotic ATP-citrate synthase (ACLY) (), also known as ATP citrate lyase. In bacteria and archaea, ATP citrate synthase is composed of two distinct subunits []. In eukaryotes, ATP citrate synthase is a homotetramer of a single large polypeptide, and is used to produce cytosolic acetyl-CoA from mitochondrial produced citrate [, , , ]. Acetyl-CoA is the building block for de novo lipid synthesis. As such, ACLY couples energy metabolism with fatty acids synthesis and plays a critical role in supporting cell growth []. Short Name:  ATP-citrate_synthase
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0 Child Features

7 Contains

DB identifier Type Name
IPR005811 Domain ATP-citrate lyase/succinyl-CoA ligase
IPR016143 Domain Citrate synthase-like, small alpha subdomain
IPR016102 Domain Succinyl-CoA synthetase-like
IPR013816 Domain ATP-grasp fold, subdomain 2
IPR003781 Domain CoA-binding
IPR017866 Conserved_site Succinyl-CoA synthetase, beta subunit, conserved site
IPR017440 Active_site ATP-citrate lyase/succinyl-CoA ligase, active site

1 Cross References

Identifier
PIRSF036511

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003878 IPR014608
GO:0006085 IPR014608
GO:0006101 IPR014608

3 Ontology Annotations

GO Term Gene Name
GO:0003878 IPR014608
GO:0006085 IPR014608
GO:0006101 IPR014608

0 Parent Features

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16952946
            16007201
            1371749
            10794176
            2295639
            23932781