Protein Domain : IPR010982

Type:  Domain Name:  Lambda repressor-like, DNA-binding domain
Description:  Bacteriophage lambdaC1 repressor controls the expression of viral genes as part of the lysogeny/lytic growth switch. C1 is essential for maintaining lysogeny, where the phage replicates non-disruptively along with the host. If the host cell is threatened, then lytic growth is induced. The Lambda C1 repressor consists of two domains connected by a linker: an N-terminal DNA-binding domain that also mediates interactions with RNA polymerase, and a C-terminal dimerisation domain []. The DNA-binding domain consists of four helices in a closed folded leaf motif. Several different phage repressors from different helix-turn-helix families contain DNA-binding domains that adopt a similar topology. These include the Lambda Cro repressor, Bacteriophage 434C1 and Cro repressors, P22 C2 repressor, and Bacteriophage MuNer protein.The DNA-binding domain of Bacillus subtilisspore inhibition repressor SinR is identical to that of phage repressors []. SinR represses sporulation, which only occurs in response to adverse conditions. This provides a possible evolutionary link between the two adaptive responses of bacterial sporulation and prophage induction.Other DNA-binding domains also display similar structural folds to that of Lambda C1. These include bacterial regulators such as the purine repressor (PurR), the lactose repressor (Lacr) and the fructose repressor (FruR), each of which has an N-terminal DNA-binding domain that exhibits a fold similar to that of lambda C1, except that they lack the first helix [, , ]. POU-specific domains found in transcription factors such as in Oct-1, Pit-1 and Hepatocyte nuclear factor 1a (LFB1/HNF1) display four-helical fold DNA-binding domains similar to that of Lambda C1 [, , ]. The N-terminal domain of cyanase has an alpha-helix bundle motif similar to Lambda C1, but it probably does not bind DNA. Cyanase is an enzyme found in bacteria and plants that catalyses the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide in response to extracellular cyanate []. Short Name:  Lambda_DNA-bd_dom
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3 Child Features

DB identifier Type Name
IPR001387 Domain Cro/C1-type helix-turn-helix domain
IPR027910 Domain YdiL-like domain
IPR000843 Domain Transcription regulator HTH, LacI

0 Contains

3 Cross Referencess

Identifier
PF13413
G3DSA:1.10.260.40
SSF47413

13 Found Ins

DB identifier Type Name
IPR008076 Family Cyanate hydratase
IPR000327 Domain POU-specific domain
IPR010744 Family Bacteriophage CI repressor
IPR016362 Family POU-domain transcription factor, class 3
IPR006899 Domain Hepatocyte nuclear factor 1, N-terminal
IPR004451 Family Conserved hypothetical protein CHP00270
IPR000972 Family Octamer-binding transcription factor
IPR015584 Family POU domain-containing protein, class 4-related
IPR015585 Family POU domain-containing protein, class 5
IPR015586 Family Pituitary-specific positive transcription factor 1
IPR022452 Family Zinc finger/helix-turn-helix protein, YgiT
IPR015060 Family Protein of unknown function DUF1870
IPR020886 Family Transcription regulator HTH, Cro/C1-type DNA-binding

1 GO Annotation

GO Term Gene Name
GO:0003677 IPR010982

1 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR010982

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
49133 D8SNC7 PAC:15422798 Selaginella moellendorffii 141  
402493 D8QQU3 PAC:15404333 Selaginella moellendorffii 143  
140650 D8QS84 PAC:15408214 Selaginella moellendorffii 140  
evm.TU.contig_47354.1 PAC:16432402 Carica papaya 61  
evm.model.supercontig_110.43 PAC:16405808 Carica papaya 225  
evm.model.supercontig_23.114 PAC:16414160 Carica papaya 145  
evm.model.supercontig_4.128 PAC:16419206 Carica papaya 357  
evm.model.supercontig_44.21 PAC:16420158 Carica papaya 164  
evm.model.supercontig_77.11 PAC:16426065 Carica papaya 142  
29912.m005549 B9RKT7 PAC:16813424 Ricinus communis 146  
30131.m007195 B9RGA6 PAC:16819016 Ricinus communis 347  
30146.m003484 B9RQC2 PAC:16819606 Ricinus communis 147  
30254.m000018 B9TJX9 PAC:16824305 Ricinus communis 331  
30801.m000020 B9THJ2 PAC:16824627 Ricinus communis 280  
30925.m000022 B9THV5 PAC:16824703 Ricinus communis 164  
30946.m000020 B9TIK3 PAC:16824722 Ricinus communis 355  
31410.m000018 B9TMH8 PAC:16825008 Ricinus communis 233  
31470.m000019 B9TFT5 PAC:16825046 Ricinus communis 285  
32697.m000028 B9TH72 PAC:16825522 Ricinus communis 109  
32902.m000030 B9TGR6 PAC:16825612 Ricinus communis 295  
33330.m000021 B9THW4 PAC:16825783 Ricinus communis 83  
33846.m000036 B9TEQ8 PAC:16826015 Ricinus communis 100  
33645.m000024 B9TG75 PAC:16825940 Ricinus communis 186  
34130.m000030 B9TCH7 PAC:16826104 Ricinus communis 210  
34609.m000037 B9TGT5 PAC:16826280 Ricinus communis 89  
35504.m000026 B9THT2 PAC:16826646 Ricinus communis 137  
35380.m000017 B9TFL3 PAC:16826583 Ricinus communis 318  
37861.m000020 B9TQA4 PAC:16827075 Ricinus communis 83  
39767.m000014 B9TQS8 PAC:16827238 Ricinus communis 93  
39476.m000013 B9TLG4 PAC:16827205 Ricinus communis 353  

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9009203
            10801492
            9799632
            10892750
            7973627
            10700279
            9237914
            11583619
            12453420