Protein Domain : IPR000327

Type:  Domain Name:  POU-specific domain
Description:  POU proteins are eukaryotic transcription factors containing a bipartite DNA binding domain referred to as the POU domain. The acronym POU (pronounced 'pow') is derived from the names of three mammalian transcription factors, the pituitary-specific Pit-1, the octamer-binding proteins Oct-1 and Oct-2, and the neural Unc-86 from Caenorhabditis elegans. POU domain genes have been identified in diverse organisms including nematodes, flies, amphibians, fish and mammals but have not been yet identified in plants and fungi. The various members of the POU family have a wide variety of functions, all of which are related to the function of the neuroendocrine system [] and the development of an organism []. Some other genes are also regulated, including those for immunoglobulin light and heavy chains (Oct-2) [, ], and trophic hormone genes, such as those for prolactin and growth hormone (Pit-1). The POU domain is a bipartite domain composed of two subunits separated by a non-conserved region of 15-55 aa. The N-terminal subunit is known as the POU-specific (POUs) domain (), while the C-terminal subunit is a homeobox domain (). 3D structures of complexes including both POU subdomains bound to DNA are available. Both subdomains contain the structural motif 'helix-turn-helix', which directly associates with the two components of bipartite DNA binding sites, and both are required for high affinity sequence-specific DNA-binding. The domain may also be involved in protein-protein interactions []. The subdomains are connected by a flexible linker [, , ]. In proteins a POU-specific domain is always accompanied by a homeodomain. Despite of the lack of sequence homology, 3D structure of POUs is similar to 3D structure of bacteriophage lambda repressor and other members of HTH_3 family [, ].This entry represents the POU-specific subunit of the POU domain. Short Name:  POU_dom
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0 Child Features

1 Contains

DB identifier Type Name
IPR010982 Domain Lambda repressor-like, DNA-binding domain

5 Cross Referencess

Identifier
PF00157
PS00035
PS00465
PS51179
SM00352

5 Found Ins

DB identifier Type Name
IPR016362 Family POU-domain transcription factor, class 3
IPR000972 Family Octamer-binding transcription factor
IPR015584 Family POU domain-containing protein, class 4-related
IPR015585 Family POU domain-containing protein, class 5
IPR015586 Family Pituitary-specific positive transcription factor 1

2 GO Annotations

GO Term Gene Name
GO:0003700 IPR000327
GO:0006355 IPR000327

2 Ontology Annotations

GO Term Gene Name
GO:0003700 IPR000327
GO:0006355 IPR000327

0 Parent Features

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Cucsa.214460.1 PAC:16969552 Cucumis sativus 58  
PGSC0003DMP400059519 PAC:37479723 Solanum tuberosum 115  

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8462099
            8156594
            1628619
            1967821
            1967834
            11159814
            11183772
            9009203