Protein Domain : IPR001387

Type:  Domain Name:  Cro/C1-type helix-turn-helix domain
Description:  The cro/C1-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 residues present in transcriptional regulators. The domain isnamed after the transcriptional repressors cro and C1 of temperate bacteriophages 434 and lambda, respectively. Besides in bacteriophages,cro/C1-type regulators are present in prokaryotes and in eukaryotes. The helix-turn-helix DNA-binding motif is generally located in the N-terminal partof these transcriptional regulators. The C-terminal part may contain an oligomerization domain, e.g. C1 repressors and CopR act as dimers, while SinRis a tetramer. The cro/C1-type HTH domain also occurs in combination with the TPR repeat and the C-terminal part of C-5 cytosine-specific DNA methylasescontains regions related to the enzymatic function.Several structures of cro/C1-type transcriptional repressors have been resolved and their DNA-binding domain encompasses five alpha helices, of whichthe extremities are less conserved []. The helix-turn-helixmotif comprises the second and third helices, the third being called the recognition helix. The HTH is involved in DNA-binding into the major groove,where the recognition helix makes most DNA-contacts. The bacteriophage repressors regulate lysogeny/lytic growth by binding with differentialaffinity to the operators. These operators show 2-fold symmetry and the repressors bind as dimers. Binding of the repressor to the operator positions the DNA backbone into a slightly bent twist [, ]. Short Name:  Cro/C1-type_HTH
Paste the following link

0 Child Features

0 Contains

4 Cross Referencess

Identifier
PF01381
PF13443
PS50943
SM00530

10 Found Ins

DB identifier Type Name
IPR016429 Family Bifunctional transcriptional regulator NadR
IPR016472 Family Transcription regulator, MJ0621, predicted
IPR016759 Family HTH-type transcriptional repressor RghR
IPR017158 Family Transcription regulator, CBS domain-containing, predicted
IPR022452 Family Zinc finger/helix-turn-helix protein, YgiT
IPR020886 Family Transcription regulator HTH, Cro/C1-type DNA-binding
IPR017271 Family Transcription regulator HTH, MJ1545, predicted
IPR017507 Family Transcription regulator, HipB-like
IPR013430 Family Toxin-antitoxin system, antidote protein, HigA
IPR013435 Family Mobile mystery protein A

1 GO Annotation

GO Term Gene Name
GO:0043565 IPR001387

1 Ontology Annotations

GO Term Gene Name
GO:0043565 IPR001387

1 Parent Features

DB identifier Type Name
IPR010982 Domain Lambda repressor-like, DNA-binding domain

894 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
140650 D8QS84 PAC:15408214 Selaginella moellendorffii 140  
evm.model.supercontig_23.114 PAC:16414160 Carica papaya 145  
evm.model.supercontig_77.11 PAC:16426065 Carica papaya 142  
29912.m005549 B9RKT7 PAC:16813424 Ricinus communis 146  
30925.m000022 B9THV5 PAC:16824703 Ricinus communis 164  
30946.m000020 B9TIK3 PAC:16824722 Ricinus communis 355  
32697.m000028 B9TH72 PAC:16825522 Ricinus communis 109  
32902.m000030 B9TGR6 PAC:16825612 Ricinus communis 295  
33330.m000021 B9THW4 PAC:16825783 Ricinus communis 83  
33846.m000036 B9TEQ8 PAC:16826015 Ricinus communis 100  
35504.m000026 B9THT2 PAC:16826646 Ricinus communis 137  
35380.m000017 B9TFL3 PAC:16826583 Ricinus communis 318  
39767.m000014 B9TQS8 PAC:16827238 Ricinus communis 93  
41455.m000013 B9TKX7 PAC:16827412 Ricinus communis 233  
51293.m000018 B9TM74 PAC:16828377 Ricinus communis 141  
52869.m000014 B9TPU2 PAC:16828569 Ricinus communis 252  
55481.m000022 B9TNI0 PAC:16828815 Ricinus communis 76  
59441.m000014 B9TL94 PAC:16829256 Ricinus communis 110  
27894.m000799 B9SEW6 PAC:16799437 Ricinus communis 114  
Cucsa.384830.1 A0A0A0KGV6 PAC:16982470 Cucumis sativus 142  
Cucsa.116320.1 A0A0A0LFV9 PAC:16960547 Cucumis sativus 145  
Cucsa.116320.2 PAC:16960548 Cucumis sativus 130  
orange1.1g038591m A0A067EGK7 PAC:18095216 Citrus sinensis 82  
orange1.1g031871m A0A067DZE6 PAC:18105581 Citrus sinensis 151  
orange1.1g032366m A0A067DVG2 PAC:18105582 Citrus sinensis 142  
AT3G58680.1 Q9LXT3 PAC:19659923 Arabidopsis thaliana 142  
AT3G24500.1 Q9LV58 PAC:19661131 Arabidopsis thaliana 148  
AT2G42680.1 Q9SJI8 PAC:19642090 Arabidopsis thaliana 142  
Thhalv10017391m V4P141 PAC:20179830 Eutrema salsugineum 142  
Thhalv10006302m V4LWF1 PAC:20190079 Eutrema salsugineum 142  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3187531
            11972345