| Type: | Family | Name: | Transcription regulator HTH, Cro/C1-type DNA-binding |
| Description: | This is a family of archaeal proteins that contain a cro/C1-type HTH domain. The cro/C1-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 residues present in transcriptional regulators. The domain is named after the transcriptional repressors Cro and C1 of temperate bacteriophages 434 and lambda, respectively. Besides in being the bacteriophages, cro/C1-type regulators are present in prokaryotes and in eukaryotes. The helix-turn-helix DNA-binding motif is generally located in the N-terminal part of these transcriptional regulators. The C-terminal part may contain an oligomerisation domain, e.g. C1 repressors and CopR act as dimers, while SinR is a tetramer. The cro/C1-type HTH domain also occurs in combination with the TPR repeat and the C-terminal part of C-5 cytosine-specific DNA methylases contains regions related to the enzymatic function (see ). | Short Name: | Tscrpt_reg_HTH_Cro/C1 |
